- 3-Bromo-5-iodo-pyridine
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- $0.00 / 1kg
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2025-12-01
- CAS:233770-01-9
- Min. Order: 1kg
- Purity: 98%min
- Supply Ability: 500KGS
- 3-Bromo-5-iodo-pyridine
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- $1.10 / 1g
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2025-11-18
- CAS:233770-01-9
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons min
- 3-Bromo-5-iodopyridine
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- $0.00 / 1KG
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2022-01-27
- CAS:233770-01-9
- Min. Order: 1KG
- Purity: 97.5%
- Supply Ability: 100 tons
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| | 3-Bromo-5-iodo-pyridine Basic information |
| | 3-Bromo-5-iodo-pyridine Chemical Properties |
| Melting point | 127-131 °C | | Boiling point | 266.5±25.0 °C(Predicted) | | density | 2.347±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 0.85±0.20(Predicted) | | form | Solid | | color | Off-white | | Water Solubility | Slightly soluble in water. | | Sensitive | Light Sensitive | | InChI | InChI=1S/C5H3BrIN/c6-4-1-5(7)3-8-2-4/h1-3H | | InChIKey | AOOZLVWDZUPEHT-UHFFFAOYSA-N | | SMILES | C1=NC=C(I)C=C1Br | | CAS DataBase Reference | 233770-01-9(CAS DataBase Reference) |
| | 3-Bromo-5-iodo-pyridine Usage And Synthesis |
| Chemical Properties | Off-white Cryst | | Uses | Reactant in the synthesis chiral 4, 4?-Bipyridines. 3-bromo-5-(trifluoromethyl)pyridine is prepared from 3-Bromo-5-iodopyridine. | | Synthesis | General procedure for the synthesis of 3-bromo-5-iodopyridine from 3,5-dibromopyridine: 3,5-dibromopyridine (0.52 g, 2.19 mmol) was dissolved in anhydrous tetrahydrofuran (4 mL) at -10 °C, keeping the internal temperature below -5 °C. Subsequently, tetrahydrofuran solution of 2M isopropylmagnesium chloride (0.25 g, 2.11 mmol) and anhydrous tetrahydrofuran solution of iodine (0.62 g, 2.11 mmol) were added sequentially and slowly and stirred for about 5 minutes. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and saturated aqueous sodium bisulfite. The organic layer was separated, dried over magnesium sulfate, filtered and concentrated to afford 3-bromo-5-iodopyridine (4.85 g, 98% yield), which can be used directly for further purification. The product characterization data were as follows: 1H NMR (400 MHz, CDCl3) δ 7.54-7.51 (m, 1H), 8.26 (s, 1H), 8.42 (s, 1H); MS (ES): m/z = 284 [M + H]+. | | References | [1] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 35
[2] Chemistry - A European Journal, 2010, vol. 16, # 41, p. 12425 - 12433
[3] European Journal of Organic Chemistry, 2002, # 2, p. 327 - 330
[4] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 12; 27
[5] Recueil des Travaux Chimiques des Pays-Bas, 1955, vol. 74, p. 1062,1068 |
| | 3-Bromo-5-iodo-pyridine Preparation Products And Raw materials |
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