- 5-Fluoro-2-oxindole
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- $10.00 / 1KG
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2025-04-18
- CAS:56341-41-4
- Min. Order: 1KG
- Purity: 98
- Supply Ability: 1KG
- 5-Fluoro-2-oxindole
-
- $0.00 / 1kg
-
2025-04-18
- CAS:56341-41-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg
- 5-Fluoro-2-oxindole
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- $0.00 / 100G
-
2025-04-16
- CAS:56341-41-4
- Min. Order: 100G
- Purity: 98%min
- Supply Ability: 30kg/month
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| | 5-Fluoro-2-oxindole Basic information |
| | 5-Fluoro-2-oxindole Chemical Properties |
| Melting point | 143-147 °C (lit.) | | Boiling point | 307.2±42.0 °C(Predicted) | | density | 1.311±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Powder or Crystalline Powder | | pka | 12.99±0.20(Predicted) | | color | White to pale brown | | InChI | InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11) | | InChIKey | DDIIYGHHUMKDGI-UHFFFAOYSA-N | | SMILES | N1C2=C(C=C(F)C=C2)CC1=O | | CAS DataBase Reference | 56341-41-4(CAS DataBase Reference) |
| | 5-Fluoro-2-oxindole Usage And Synthesis |
| Chemical Properties | Light Yellow Crystalline | | Uses | 5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis. | | Application | 5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors. | | Preparation | synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%. | | Biological Activity | 5-Fluoro-2-oxindole has anti-inflammatory, antioxidant, anxiolytic, antidepressant and antinociceptive effects and inhibits neuropathic pain. Treatment with 5-Fluoro-2-oxindole increased the expression of NQO1, HO-1, and MOR in the spinal cord and/or paw and inhibited CFA-induced up-regulation of phosphorylated MAPK, 4-HNE, NOS2, CD11b/c, and IBA-1. 5-Fluoro-2-oxindole ameliorated the local effects of morphine. Studies have revealed that 5-fluoro-2-oxindole inhibits plasticity, oxidative and inflammatory responses induced by peripheral inflammation and enhances the antinociceptive effects of morphine. Thus, the use of 5-fluoro-2-indole alone and/or in combination with morphine are two remarkable new approaches for the treatment of chronic inflammatory pain. |
| | 5-Fluoro-2-oxindole Preparation Products And Raw materials |
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