| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:ASS234;ASS234,ASS-234
CAS:1334106-34-1
Purity:98% Package:5 mg
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| Product Name: | ASS234 | | Synonyms: | ASS234;ASS234,ASS-234;1H-Indole-2-methanamine, N,1-dimethyl-5-[3-[1-(phenylmethyl)-4-piperidinyl]propoxy]-N-2-propyn-1-yl- | | CAS: | 1334106-34-1 | | MF: | C29H37N3O | | MW: | 443.62 | | EINECS: | | | Product Categories: | | | Mol File: | 1334106-34-1.mol |  |
| | ASS234 Chemical Properties |
| Boiling point | 582.5±45.0 °C(Predicted) | | density | 1.05±0.1 g/cm3(Predicted) | | pka | 8.96±0.10(Predicted) |
| | ASS234 Usage And Synthesis |
| Enzyme inhibitor | he multi-target enzyme inhibitor (FW = g/mol), also known as N-((5-(3- (1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N- methylprop-2-yn-1-amine, bears the MAO-inhibiting propargyl group attached to a cholinesterase-inhibiting donepezil moiety retains the ability to inhibit human acetyl- and butyryl-cholinesterases as well as monamine oxidases. With a kinact/KI value of 3 × 106 min? 1 M? 1 , ASS234 inhibition of MAO A and MAO B by ASS234 is almost as effective as clorgyline. It also forms the same N5 -adduct with the isoalloxazine ring of the FAD cofactor. The kinetic studies demonstrate that ASS234 is not only a reversible inhibitor of both acetyl and butyryl-cholinesterases with μM affinity, but is also a highly potent irreversible inhibitor of MAO A similarly to clorgyline. |
| | ASS234 Preparation Products And Raw materials |
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