Company Name: |
Adamas Reagent, Ltd.
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Tel: |
400-6009262 16621234537 |
Email: |
zhangsn@titansci.com |
Products Intro: |
Product Name:Metoclopramide-d3 CAS:1216522-89-2 Purity:对照品 Package:10mg~500mg Remarks:AC000575D01
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| METOCLOPRAMIDE-D3 Basic information |
| METOCLOPRAMIDE-D3 Chemical Properties |
Melting point | 143-148°C | storage temp. | -20°C Freezer | solubility | Chloroform (Slightly), Methanol (Slightly) | form | Solid | color | White |
| METOCLOPRAMIDE-D3 Usage And Synthesis |
Description | Metoclopramide-d3 is intended for use as an internal standard for the quantification of metoclopramide by GC- or LC-MS. Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes. It is also a dopamine D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents. | Chemical Properties | White Crystalline Solid | Uses | Labelled dopamine D2 receptor antagonist. A labelled substituted benzamide with neuroleptic activity. Antiemetic. |
| METOCLOPRAMIDE-D3 Preparation Products And Raw materials |
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