| Company Name: |
LGC Science (Shanghai) Ltd.
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| Tel: |
17717235263 |
| Email: |
cindy.yang@lgcgroup.com |
| Products Intro: |
Product Name:4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one
CAS:1460272-53-0
Purity:具体纯度，见COA Package:25mg Remarks:TRC-C992278
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| | Olaparib Metabolite M15 Basic information |
| Product Name: | Olaparib Metabolite M15 | | Synonyms: | Olaparib Metabolite M15;1(2H)-Phthalazinone, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]hydroxymethyl]- | | CAS: | 1460272-53-0 | | MF: | C24H23FN4O4 | | MW: | 450.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1460272-53-0.mol |  |
| | Olaparib Metabolite M15 Chemical Properties |
| density | 1.50±0.1 g/cm3(Predicted) | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | pka | 11.69±0.20(Predicted) | | form | Solid | | color | White to Off-White |
| | Olaparib Metabolite M15 Usage And Synthesis |
| Uses | 4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one is an impurity of Olaparib (O514500), a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy. Potent PARP inhibitor. |
| | Olaparib Metabolite M15 Preparation Products And Raw materials |
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