密朗丁
| 中文名称 | 密朗丁 |
|---|---|
| 中文同义词 | 1-甲基-3-苯基吡咯烷-2,5-二酮;苯琥胺;米浪丁;密朗丁;1-甲基-3-苯基-2,5-吡咯烷二酮;苯琥胺 USP标准品;化合物 T25945 |
| 英文名称 | PHENSUXIMIDE |
| 英文同义词 | (.+/-.)-N-Methyl-2-phenylsuccinimide;1-Methyl-3-phenyl-2,5-pyrrolidinedione;1-methyl-3-phenyl-5-pyrrolidinedione;1-Methyl-3-phenylpyrrolidin-2,5-dione;1-methyl-3-phenyl-pyrrolidine-2,5-quinone;Phensuximide (500 mg);PHENSUCCIMIDE;1-Methyl-3-Phenylsuccinimide |
| CAS号 | 86-34-0 |
| 分子式 | C11H11NO2 |
| 分子量 | 189.21 |
| EINECS号 | 201-664-6 |
| 相关类别 | MILONTIN |
| Mol文件 | 86-34-0.mol |
| 结构式 |  |
密朗丁 性质
| 熔点 | 71-73° |
|---|---|
| 沸点 | 324.47°C (rough estimate) |
| 密度 | 1.1596 (rough estimate) |
| 折射率 | 1.5012 (estimate) |
| 储存条件 | Refrigerator |
| 溶解度 | 氯仿（微溶）、乙酸乙酯（微溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | -1.86±0.40(Predicted) |
| 颜色 | 白色至类白色 |
| 水溶解性 | 4.2g/L(25 ºC) |
IC50: cyclic AMP and cyclic GMP accumulation
Phensuximide produce depolarization-induced accumulation of cyclic GMP or cyclic AMP levels with ID 50 values of 8.00 mM or 6.20 mM in incubated slices of mouse cerebral cortex.Phensuximide (0.5-2.0 mM) has the ability to competitively inhibit mephenytoin 4-hydroxylase activity in human liver microsomes, the K i and K m values are 559 μM and 235 μM, respectively.
Phensuximide (intraperitoneal injection; 1.25 mmol/kg; single dose) induces mild changes in renal function, including: trace hematuria, increased proteinuria and decreased paminohippurate uptake in Sprague-Dawley rats.Phensuximide (intraperitoneal injection; 0.3 or 0.6 mmol/kg; 5-7 days) results in transient hematuria and proteinuria, but no change in the other renal function parameters studied. It is concluded that phensuximide produces mild, transient renal effects in Fischer 344 rats, and that the Fischer 344 rat is a suitable model for studying phensuximide-induced toxicity to the urinary tract.
| Animal Model: | Fischer 344 rats |
| Dosage: | 0.3 or 0.6 mmol/kg |
| Administration: | Intraperitoneal injection; 5-7 days |
| Result: | Induced urotoxicity following daily administration for 5-7 days in Fischer 344 rats. |
安全信息
| 海关编码 | 2925190100 |
|---|---|
| 毒性 | LD50 orally in mice: 960 mg/kg (Chen, Ensor) |
密朗丁 化学药品说明书
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B1730 | Phensuximide | 5 mg | 687元 | |
| 2024/01/25 | HY-B1730 | 密朗丁 Phensuximide | 86-34-0 | 10mg | 1100元 |