AZD7507 manufacturers
- AZD7507
-
- $48.00 / 1mg
-
2025-11-10
- CAS:1041852-85-0
- Min. Order:
- Purity: 99.55%
- Supply Ability: 10g
- AZD7507
-
- $48.00 / 1mg
-
2025-11-10
- CAS:1041852-85-0
- Min. Order:
- Purity: 99.55%
- Supply Ability: 10g
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| | AZD7507 Basic information |
| Product Name: | AZD7507 | | Synonyms: | AZD7507;AZD7507; AZD-7507; AZD 7507;1041852-85-0;CS-2850;4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide;3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-;AZD7507,AZD 7507,Inhibitor,AZD-7507,CSF-1R,CSF1R,CSF-1 receptor,c-Fms,inhibit,colony stimulating factor 1 receptor;AZD7507, 10 mM in DMSO | | CAS: | 1041852-85-0 | | MF: | C23H27FN6O3 | | MW: | 454.5 | | EINECS: | | | Product Categories: | | | Mol File: | 1041852-85-0.mol |  |
| | AZD7507 Chemical Properties |
| Boiling point | 680.7±65.0 °C(Predicted) | | density | 1.346±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 14.47±0.30(Predicted) | | color | Light yellow to yellow |
| | AZD7507 Usage And Synthesis |
| Uses | AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity. | | in vivo | AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC50 is >20 μM[1]. AZD7507 significantly decreases the number of CD68+ macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells[2]. | | References | [1] Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. DOI:10.1016/j.bmcl.2013.06.031
[2] Boulter L, et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Send to J Clin Invest. 2015 Mar 2;125(3):1269-85. DOI:10.1172/JCI76452 |
| | AZD7507 Preparation Products And Raw materials |
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