6-氮杂胸腺嘧啶
| 中文名称 | 6-氮杂胸腺嘧啶 |
|---|---|
| 中文同义词 | 6-氮杂胸腺嘧啶;6-吖胸嘧啶;6-氮胸嘧啶;氮杂胸腺嘧啶;氮杂胸腺嘧啶,6;1,2,4-三嗪-3,5(2H,4H)-二酮,6-甲基-;3,5-二羟基-6-甲基-1,2,4-三嗪;5-甲基-6-氮尿嘧啶 |
| 英文名称 | 6-AZATHYMINE |
| 英文同义词 | 1,2,4-TRIAZINE-3,5(2H,4H)-DIONE, 6-METHYL-;6-AZA-5-METHYLURACIL;6-AZA-2,4-DIHYDROXY-5-METHYL-PYRIMIDINE;6-AZATHYMINE;6-METHYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE;3,5-DIHYDROXY-6-METHYL-1,2,4-TRIAZINE;6-Azathymine,98%;6-METHYL-S-TRIAZINE-3,5-DIONE |
| CAS号 | 932-53-6 |
| 分子式 | C4H5N3O2 |
| 分子量 | 127.1 |
| EINECS号 | 213-253-9 |
| 相关类别 | 酰胺;酰胺化合物;Vitamins and Derivatives;Nucleic acids |
| Mol文件 | 932-53-6.mol |
| 结构式 |  |
6-氮杂胸腺嘧啶 性质
| 熔点 | 210-212°C |
|---|---|
| 沸点 | 235.85°C (rough estimate) |
| 密度 | 1.4748 (rough estimate) |
| 折射率 | 1.5000 (estimate) |
| 酸度系数(pKa) | 7.6(at 25℃) |
| 形态 | 粉末晶体 |
| 颜色 | 白色到近乎白色 |
| Merck | 14,903 |
| BRN | 126863 |
| InChI | InChI=1S/C4H5N3O2/c1-2-3(8)5-4(9)7-6-2/h1H3,(H2,5,7,8,9) |
| InChIKey | XZWMZFQOHTWGQE-UHFFFAOYSA-N |
| SMILES | N1=C(C)C(=O)NC(=O)N1 |
| CAS 数据库 | 932-53-6(CAS DataBase Reference) |
6-Azathymine，胸腺嘧啶的 6-氮类似物，是一种有效的 D-3-氨基异丁酸酯-丙酮酸氨基转移酶 (D-3-aminoisobutyrate-pyruvate aminotransferase) 抑制剂。6-Azathymine 可抑制 DNA 的生物合成，并具有抗菌和抗病毒活性。
6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine.
The administration of 6-Azathymine to the mouse leads to the urinary elimination not only of free Azathymine, but also of various metabolites of it. Following the administration of 6-Azathymine-5- 14 C to mice, radioactivity is found in all tissues investigated, not only in the form of free Azathymine, but also as metabolic derivatives.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| RTECS号 | XY8050000 |
| 海关编码 | 2934.10.9000 |
| 危险等级 | IRRITANT |