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BTZ-N3

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BTZ-N3 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:BTZ-N3；BTZ N3;BTZN3
CAS:1839081-05-8
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:BTZ-N3;BTZN3,BTZ-N-3
CAS:1839081-05-8
Purity:98% Package:5 mg
BTZ-N3 Basic information
Product Name:BTZ-N3
Synonyms:BTZ-N3;BTZN3,BTZ-N-3
CAS:1839081-05-8
MF:C17H16F3N5O3S
MW:427.4
EINECS:
Product Categories:
Mol File:1839081-05-8.mol
BTZ-N3 Structure
BTZ-N3 Chemical Properties
Safety Information
MSDS Information
BTZ-N3 Usage And Synthesis
DescriptionBTZ-N3 is a potent and selective anti-TB drug candidate. BTZ-N3 is a related click chemistry products based on the molecular mode of activation of BTZ043. BTZ-N3 binds in the essentially same pocket as that of BTZ043. Detailed biochemical studies with cell envelope enzyme fractions_x000D_ of Mycobacterium smegmatis combined with the model biochemical reactivity studies with nucleophiles indicated that, in contrast to BTZ043, the azide analogue may have a different mode of activation for anti-TB activity. Subsequent enzymatic studies with recombinant DprE1 from Mtb followed by MIC determination in NTB1 strain of Mtb (harboring Cys387Ser mutation in DprE1 and is BTZ043 resistant) unequivocally indicated that BTZ-N3 is an effective reversible and noncovalent inhibitor of DprE1.
BTZ-N3 Preparation Products And Raw materials
Tag:BTZ-N3(1839081-05-8) Related Product Information