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Lincomycin

Lincomycin Suppliers list
Company Name: Guangzhou PI PI Biotech Inc
Tel: ; +8618371201331;+8618371201331
Email: sales@pipitech.com;87478684@qq.com
Products Intro: Product Name:Clindamycin Phosphate EP Impurity A
CAS:154-21-2
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:(2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl ]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside
Company Name: XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Tel: +8617731987558
Email: xingjiu@xingjiubiotech.com
Products Intro: Product Name:Lincomycine
CAS:154-21-2
Purity:99.9% Package:1KG;200USD
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:Lincomycin
CAS:154-21-2
Purity:As coa Package:As request Remarks:154-21-2
Company Name: SHANDONG ZHI SHANG CHEMICAL CO.LTD
Tel: +86 18953170293
Email: sales@sdzschem.com
Products Intro: Product Name:Lincomycin
CAS:154-21-2
Purity:0.99 Package:5KG;1KG
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +8619930503282
Email: alice@crovellbio.com
Products Intro: Product Name:Lincomycin
CAS:154-21-2
Purity:99% Package:1PCS;1USD

Lincomycin manufacturers

  • Lincomycine
  • $200.00 / KG
  • 2021-12-09
  • CAS:154-21-2
  • Min. Order: 1KG
  • Purity: 99.9%
  • Supply Ability: 500MT/month
  • Lincomycin HCl
  • $10.00 / Kg/Drum
  • 2021-12-01
  • CAS:154-21-2
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 10 ton
  • Lincomycin USP/EP/BP
  • $1.10 / g
  • 2021-06-24
  • CAS:154-21-2
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
Lincomycin Basic information
Product Name:Lincomycin
Synonyms:U-10149A;LINCOMYCIN STANDARD;LINCOMYCIN;LYNCOMYCIN;Lincomycin HCL Bp98 USP24 EPIII CP2000;Lincomycin hydrochoride;Lincomycin(baseand/orunspecifiedsalt);Albiotic
CAS:154-21-2
MF:C18H34N2O6S
MW:406.54
EINECS:205-824-6
Product Categories:13C & 2H Sugars;Carbohydrates & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:154-21-2.mol
Lincomycin Structure
Lincomycin Chemical Properties
Melting point 148-150°C
Boiling point 646.8±55.0 °C(Predicted)
density 1.1704 (rough estimate)
refractive index 1.6510 (estimate)
pka7.6(at 25℃)
NIST Chemistry ReferenceLincomycin(154-21-2)
EPA Substance Registry SystemLincomycin (154-21-2)
Safety Information
Hazardous Substances Data154-21-2(Hazardous Substances Data)
ToxicityLD50 oral in rat: 1gm/kg
Lincomycin Usage And Synthesis
DescriptionLincomycin is an antibiotic active against grampositive bacteria. Occupational exposure occurs in poultry and pig breeders.
Chemical PropertiesWhite Crystalline Solid
OriginatorLincocin,Upjohn,UK,1964
UsesLincomycin (Clindamycin Phosphate EP Impurity A) is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.This compound is a contaminant of emerging concern (CECs).
UsesAn antibiotic produced by Streptomyces lincolnensis. Antibacterial
UsesLincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N-methylproline, coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
DefinitionChEBI: A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.
Manufacturing ProcessAs described in US Patent 3,086,912, the process comprises cultivating Streptomyces lincolnensis var. lincolnensis in an aqueous nutrient medium containing a source of assimilable carbohydrate and assimilable nitrogen under aerobic conditions until substantial activity is imparted to the medium by production of lincolnensin and isolating the lincolnensin so produced.
Brand nameLincocin (Pharmacia & Upjohn).
Therapeutic FunctionAntibacterial
Antimicrobial activityLincomycin has an antibacterial effect with respect to Gram-positive microorganisms (staphylococci, streptococci, pneumococci, diphtheria bacillus, and clostridia). It is used for serious bacterial infections: sepsis, osteomyelitis, septic endocarditis, pneumonia, pulmonary abscess, infected wounds, and purulent meningitis. Lincomycin is a reserve drug for infections caused by strains of staphylococci and other Gram-positive microorganisms that are resistant to penicillin and other antibiotics. Synonyms of this drug are lincocin, mycivin, albiotic, and others.
Contact allergensLincomycin is an antibiotic of the lincosanide group,active against Gram-positive bacteria. Occupational exposure occurs in poultry and pig breeders
Clinical UseLincomycin is a natural product isolated from fermentations of Streptomyces lincolnensisvar. lincolnensis. It is active against Gram-positive organisms, including some anaerobes. It is indicated for the treatment of serious infections caused by sensitive strains of streptococci, pneumococci, and staphylococci. It generally is reserved for patients who are allergic to penicillin because of the increased risk of pseudomembranous colitis. It also serves as the starting material for the synthesis of clindamycin (by a SN-2 reaction that inverts the R stereochemistry of the C-7 hydroxyl to a C-7 S-chloride).
Chemical SynthesisLincomycin, 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidincarboxamido)-1-methylthio-D-erythro-α-D-galacto-octopyranoside (32.5.1), is the first lincosamide that has found use in clinical practice, and which was isolated in 1962 from the culture liquid of the activity of the actinomycete Streptomyces lincolnensis.
Veterinary Drugs and TreatmentsLincomycin has dosage forms approved for use in dogs, cats, swine, and in combination with other agents for chickens. Because clindamycin is generally better absorbed, more active, and probably less toxic, it has largely supplanted the use of lincomycin for oral and injectable therapy in small animals, but some clinicians believe that clindamycin does not offer enough clinically significant improvements over lincomycin to justify its higher cost. For further information, refer to the Pharmacology or Doses sections.
Tag:Lincomycin(154-21-2) Related Product Information
Lincomycin 2,7-diacetate Lincomycin HCL BP98/USP24 Lincomycin-d3 LINCOMYCIN HCL LINCOMYCIN HYDROCHLORIDE MONOHYDRATE USP FOR INJECTABLES Lincomycin HCL JP14 Lincomycin Propyl butyrate Dideoxyadenosine(Dda) METHYL-2-PYRROLIDONE 1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXYLIC ACID [2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-TETRAHYDRO-PYRAN-2-YL)-PROPYL]-AMIDE lincospectin PYRAZOPHOS Clindamycin hydrochloride Clindamycin lincomycin,hydrochloridehydrat Propyl gallate Methyl