ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21)

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Company Name: Merck KGaA  
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ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21) Basic information
Product Name:ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21)
Synonyms:Anti-UCHL1 antibody produced in rabbit;ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21);ANTI-UCH-L1;Anti-Ubiquitin thioesterase L1;Anti-Ubiquitin carboxyl-terminal hydrolase isozyme L1;Anti-Neuron cytoplasmic protein 95
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ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21) Structure
ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21) Chemical Properties
storage temp. -20°C
form buffered aqueous solution
biological sourcerabbit
Safety Information
WGK Germany 3
Storage Class10 - Combustible liquids
MSDS Information
ProviderLanguage
SigmaAldrich English
ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21) Usage And Synthesis
UsesAnti-UCHL1 antibody produced in rabbit has been used in:
  • immunohistochemistry at 1:100 dilution
  • immunofluorescence
  • proximity ligation assay
  • indirect immunolabeling at 1:1000 dilution

General DescriptionThe ubiquitin C-terminal hydrolase L1 (UCH-L1) gene is mapped to human chromosome 4p13. The protein localized in the cytosol and nucleus. UCH-L1 protein is primarily expressed in neuroendocrine tissues, neurons and in testis/ovary. Rabbit polyclonal anti-UCHL1 antibody recognizes ubiquitin carboxyl-terminal hydrolase isozyme L1.
Biochem/physiol ActionsUbiquitin C-terminal hydrolase-L1 (UCHL1) is a deubiquitinating enzyme (DUB) that hydrolyzes C-terminal ubiquitin esters and amides, and peptideubiquitin amides to ubiquitin monomers in- vitro. In addition to DUB activity, it also possesses E3 ubiquitin-protein ligase activity. UCHL1 is involved in the regulation of the ubiquitin-dependent proteolytic system. UCH-L1 plays a vital role in cancer development and progression by upstream activation of protein kinase B (Akt). Mutation in the UCHL1 gene is associated with the development of Parkinson′s disease (PD).
ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21) Preparation Products And Raw materials
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