| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:1(S),9(R)-()-Bicuculline methbromide
CAS:66016-70-4
Purity:>= 98 % HPLC, solid Package:25mg, 125mg Remarks:B7561
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Bicuculline methobromide
CAS:66016-70-4
Package:10mg
|
| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
|
| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:1(S),9(R)-()-Bicuculline methbromide
CAS:66016-70-4
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，More
|
| Company Name: |
Shanghai Fine Biotech Co.，Ltd
|
| Tel: |
18221172427 |
| Email: |
sale@fine-biotech.com |
| Products Intro: |
Product Name:1(S),9(R)-()-Bicuculline methbromide
CAS:66016-70-4
Purity:98%HPLC Package:100mg;250mg;1g;5g,10g;25g;100g
|
|
| | (-)-BICUCULLINE METHBROMIDE Basic information |
| Product Name: | (-)-BICUCULLINE METHBROMIDE | | Synonyms: | (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1);1(S),9(R)-(-)-Bicuculline methbromide;(-)-BICUCULLINE METHBROMIDE;[r-(r*,s*)]-5-(6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquindinium bromide;1(s),9(r)-(-)-bicuculline methobromide;(6R)-6-[(5S)-6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one;d-Bicuculline methobromide;(+)-Bicuculline methobromide|||d-Bicuculline methobromide|||(+)-Bicuculline methobromide | | CAS: | 66016-70-4 | | MF: | C21H20NO6.Br | | MW: | 462.294 | | EINECS: | | | Product Categories: | | | Mol File: | 66016-70-4.mol |  |
| | (-)-BICUCULLINE METHBROMIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | aqueous base: unstable | | form | solid | | color | white | | Water Solubility | Soluble to 50 mM in water |
| | (-)-BICUCULLINE METHBROMIDE Usage And Synthesis |
| Uses | 1(S),9(R)-(-)-Bicuculline methbromide has been used:
- as a γ-aminobutyric acid (GABAA) receptor A antagonist: in cortical neuron culture
- in artificial cerebrospinal fluid (ACSF) formature dentate granule neurons
- in hypothalamic explant cultures
| | Biochem/physiol Actions | 1(S),9(R)-(?)-Bicuculline methbromide is a GABAA receptor antagonist, which blocks Ca2+-activated potassium (SK) channels. It is the water-soluble derivative of (+)-bicuculline. | | in vivo | Bicuculline methobromide (subcutaneous injection, 1.25-3 mg/kg) can cause clonus-tonic convulsions in a dose-dependent manner in mice and these convulsions are enhanced by injection of the μ-opioid agonist morphine[1].
Bicuculline methobromide (subcutaneous injection, 1.5-3.2 mg/kg) induces male Swiss S mice generalized seizures with a CD50 (convulsant dose) of 2.2 mg/kg for clonus and CD50 of 2.4 mg/kg for tonus. Seizures induced by Bicuculline at the dose of 3.2 mg/kg can be blocked by pretreatment (i.p.) with the NMDA antagonists MK-801, CPP and CGS 19755[2].
| | storage | Store at RT |
| | (-)-BICUCULLINE METHBROMIDE Preparation Products And Raw materials |
|