Chaetocin

Chaetocin Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: 21-51619050
Email: ivan@atkchemical.com
Products Intro: CAS:28097-03-2
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: CAS:28097-03-2
Purity:0.99 Package:25KG;5KG;1KG;500G
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: factory@coreychem.com
Products Intro: Product Name:Chaetocin
CAS:28097-03-2
Purity:95-99% Package:1g;1USD
Company Name: Aktin Chemicals, Inc.
Tel: 028-85159085
Email: info@aktinchem.com
Products Intro: Product Name:CHAETOCIN
CAS:28097-03-2
Purity:0.98 Package:10mg;20mg;50mg;100mg;200mg;500mg;1g;10g;100g;可按照客户要求定制包装
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: Service@dideu.com
Products Intro: Product Name:CHAETOCIN FROM CHAETOMIUM MINUTUM
CAS:28097-03-2
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer

Chaetocin manufacturers

  • Chaetocin
  • $1.00 / 1g
  • 2020-01-13
  • CAS:28097-03-2
  • Min. Order: 1g
  • Purity: 95-99%
  • Supply Ability: 1ton
Chaetocin Basic information
Product Name:Chaetocin
Synonyms:chetocin;CHAETOCIN FROM CHAETOMIUM MINUTUM;CHAETOCIN(SH);(3S,3'S,5aR,5'aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-Octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone;Chaetocin A;[10b,10'b(11H,11'H)-Bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone,2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-,(3S,3'S,5aR,5'aR,10bR,10'bR,11aS,11'aS)-;HMTase Inhibitor II, Chaetocin;(3S,3'S,6R,6'R,14R,14'R,16S,16'S)-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-2,2',3,3',6,6',7,7'-octahydro-1H,1'H-[14,14'-bi(3,11a-epidithiopyrazino[1',2':1,5]pyrrolo[2,3-b]indole)]-1,1',4,4'(15H,15'H)-tet
CAS:28097-03-2
MF:C30H28N6O6S4
MW:696.84
EINECS:200-258-5
Product Categories:Miscellaneous Enzyme
Mol File:28097-03-2.mol
Chaetocin Structure
Chaetocin Chemical Properties
density 1.87±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form White to off-white solid
pka12.39±0.10(Predicted)
color White
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKeyPZPPOCZWRGNKIR-PNVYSBBASA-N
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
RIDADR 1544
WGK Germany 3
RTECS FM3032000
HazardClass 6.1(b)
PackingGroup III
HS Code 29419090
MSDS Information
Chaetocin Usage And Synthesis
DescriptionChaetocin (28097-69-1) is an antimicrobial fungal metabolite. It was found to be a specific inhibitor of the lysine-specific histone methyltransferase SU(VAR)3-9 (IC50 = 0.6 mM) of Drosophila melanogaster and of its human ortholog (IC50 = 0.8 mM). It acts as a competitive inhibitor for S-adenosylmethionine. The specificity of chaetocin for SU(VAR)3-9 makes this compound an excellent tool for the study of heterochromatin-mediated gene repression. Chaetocin has an antimyeloma activity which has been linked to induction of oxidative stress and subsequent apoptosis.
Chemical PropertiesChaetocin is supplied as a crystalline solid. A stock solution may be made by dissolving the chaetocin in the solvent of choice, which should be purged with an inert gas. Chaetocin is soluble in organic solvents such as DMSO. The solubility of chaetocin in DMSO is approximately 25 mg/ml.
UsesChaetocin is an epithiodioxopiperazine antibiotic that has recently shown promise as a selective antitumour agent. Chaetocin is an inhibitor of lysine-specific methyltransferase SU(VAR)3-9 both in vitro and in vivo. Chaetocin is dramatically accumulated in cancer cells via a process inhibited by glutathione. Inside the cell, its activity is mediated by the imposition of oxidative stress.
ApplicationChaetocin is a natural metabolite isolated from Chaetomium minutum. It is a nonspecific inhbitor of histone lysine methyltransferases which are important epigenetic enzymes . Induces apoptosis in myeloma cell lines and exhibits antiproliferative activity in mammals. Chaetocin from Chaetomium minutum has been used to determine its effects on sensitization of various cells. It has also been used to determine the biological functions of OS-induced heterochromatin formation.
General DescriptionChaetocin is a fungal metabolite with antimicrobial and cytostatic activity. It belongs to the 3,6-epidithio-diketopiperazines class of which gliotoxin, sporidesmin, aranotin, oryzachloride, verticillin A and the melinacidins are members. Chaetocin is a molecular dimer of two five-membered rings cis fused. Interestingly, the chirality of the 3,6-epidithiodioxopiperazine moiety in chaetocin is opposite to the chirality of gliotoxin, sporidesmin, aranotin, and oryzachloride. Unlike these compounds, chaetocin does not have an antiviral activity. This fungal toxin showed strong cytotoxicity against HeLa cells (IC50 = 0.05 mg/ml).
Biochem/physiol ActionsChaetocin is a competitive inhibitor for S-adenosylmethionine. The specificity of chaetocin for SU(VAR)3-9 makes this compound an excellent tool for the study of heterochromatin-mediated gene repression.
References1) Greiner et al. (2005), Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9; Nat. Chem. Biol., 1 143
2) Isham et al. (2007), Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress; Blood, 109 2579
Chaetocin Preparation Products And Raw materials
Tag:Chaetocin(28097-03-2) Related Product Information
PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]- Forskolin 1-(1-HEXYL)-PIPERAZINE 2-(3-PHENYL-PYRROLIDIN-1-YL)-ETHYLAMINE N,N'-DIACETYL-1,6-DIAMINOHEXANE 2,2'-ETHYLENEDIANILINE 3,4-DIMETHYL-3,4-DIPHENYLHEXANE HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE CHEMBRDG-BB 4012298 D-Prolinamide 1-Methylpiperazin-2-one 2,5-Dimethylpiperazine 1H-Indol-2-amine hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one 1-Methyl-3-phenyl-3-propylpyrrolidine α,β-Dimethylbibenzyl 1-(6-AMINOHEXYL)PIPERAZINE