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Product Name:Methyl (4-bromobenzoyl)-L-cysteinate
CAS:1947408-74-3
Purity:Methyl (4-bromobenzoyl)-L-cysteinate Package:100MG Remarks:907243-100MG
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ShangHai Biochempartner Co.,Ltd
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| Products Intro: |
Product Name:Methyl (4-bromobenzoyl)-L-cysteinate
CAS:1947408-74-3
Purity:98% HPLC LCMS Package:100MG;1G;5G
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| | Methyl (4-bromobenzoyl)-L-cysteinate Basic information |
| Product Name: | Methyl (4-bromobenzoyl)-L-cysteinate | | Synonyms: | Methyl (4-bromobenzoyl)-L-cysteinate;pharmacophore,inhibit,Cysteine thiol probe,products,enone-based,chromophore,thiol-based,electrophilic,Inhibitor,l-cystine,Natural;L-Cysteine, N-(4-bromobenzoyl)-, methyl ester | | CAS: | 1947408-74-3 | | MF: | C11H12BrNO3S | | MW: | 318.19 | | EINECS: | | | Product Categories: | | | Mol File: | 1947408-74-3.mol |  |
| | Methyl (4-bromobenzoyl)-L-cysteinate Chemical Properties |
| Boiling point | 465.2±45.0 °C(Predicted) | | density | 1.491±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 250 mg/mL (785.69 mM) | | pka | 9.05±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | Methyl (4-bromobenzoyl)-L-cysteinate Usage And Synthesis |
| Uses | Methyl (4-bromobenzoyl)-L-cysteinate is a chemoselective thiol probe for detection of electrophilic metabolites. As it is often difficult to isolate low-abundance natural products from extracts, metabolities with bioactivity or therapeutic potential may be missed. Castro-Falcón, et al developed a reactivity-guided approach using thiolate probes to discover electrophilic natural products - a cysteine-based probe and thiophenol-based probe. Both consist of
- A chemoselective reagent for covalent reactivity with a pharmacophore,
- A conspicuous UV/VIS or mass spectrometric (MS) tag,
- A linker between the tag and reagent. Methyl (4-bromobenzoyl)-L-cysteinate contains a bromine MS tag and phenyl bromide UV tag that was demonstrated to chemoselectively label enone-, β-lactam-, and β-lactone-based natural products.
Complementarily, a thiophenol probe (cat# 125237) with a chlorine MS tag and phenyl chloride UV tag labeled epoxide-based natural products. These probes can be used in diverse extracts (bacterial, fungal, plant) to chemically faciliate access to high-value metabolites. |
| | Methyl (4-bromobenzoyl)-L-cysteinate Preparation Products And Raw materials |
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