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| | PD 123319 ditrifluoroacetate Basic information |
| Product Name: | PD 123319 ditrifluoroacetate | | Synonyms: | 1-[[4-(DIMETHYLAMINO)-3-METHYLPHENYL]METHYL]-5-(DIPHENYLACETYL)-4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID DITRIFLUOROACETATE;(3S)-9-[(4-DIMETHYLAMINO-3-METHYL-PHENYL)METHYL]-4-(2,2-DIPHENYLACETYL)-4,7,9-TRIAZABICYCLO[4.3.0]NONA-7,10-DIENE-3-CARBOXYLIC ACID;PD 123,319;PD 123,319 DITRIFLUOROACETATE;S(+)-1-[[4-(DIMETHYLAMINO)-3-METHYLPHENYL]METHYL]-5-(DIPHENYLACETYL)-4,5,6,7-TETRAHYDRO-1H-IMIDAZOL[4,5-C]PYRIDINE-6-CARBOXYLIC ACID DITRIFLUOROACETATE;PD 123,319 DITRIFLUOROACETATE POTENT AND SELECTIVE;1-((4-(Dimethylamino)-3-methylphenyl)methyl)-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4.5-c]pyridine-6-carboxyli;pd 123,319 di(trifluoroacetate) salt | | CAS: | 130663-39-7 | | MF: | C31H32N4O3 | | MW: | 508.61 | | EINECS: | | | Product Categories: | Inhibitors;Angiotensin | | Mol File: | 130663-39-7.mol |  |
| | PD 123319 ditrifluoroacetate Chemical Properties |
| Boiling point | 775.8±60.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | H2O: 12 mg/mL | | form | powder | | pka | 2.80±0.20(Predicted) | | Water Solubility | Soluble to 100 mM in water |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| | PD 123319 ditrifluoroacetate Usage And Synthesis |
| Uses | PD 123319 is a selective non-peptide angiotensin AT2 receptor antagonist. | | Definition | ChEBI: An imidazopyridine consisting of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine having 4-(dimethylamino)-3-methylbenzyl, diphenylacetyl and carboxy and groups at positions 1, 5 and 6 respectively | | Biological Activity | Potent, selective, non-peptide angiotensin AT 2 receptor antagonist. IC 50 values are 34 and 210 nM in rat adrenal tissue and brain respectively. | | references | [1] blankley c j, hodges j c, klutchko s r, et al. synthesis and structure-activity relationships of a novel series of non-peptide angiotensin ii receptor binding inhibitors specific for the at2 subtype. journal of medicinal chemistry, 1991, 34(11): 3248-3260.
[2] boulay g, servant g, luong t t, et al. modulation of angiotensin ii binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the dup-753-sensitive angiotensin ii receptor of bovine adrenal glomerulosa. molecular pharmacology, 1992, 41(4): 809-815.
[3] siragy h. angiotensin ii receptor blockers: review of the binding characteristics. the american journal of cardiology, 1999, 84(10): 3-8. |
| | PD 123319 ditrifluoroacetate Preparation Products And Raw materials |
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