|
|
| | L-Histidine hydrochloride Basic information |
| Product Name: | L-Histidine hydrochloride | | Synonyms: | H-His-OH.xHCl;L-HISTIDINE DIHYDROCHLORIDE;Crystalline2HCl;L-Histidine hydrochloride;L-Histidine hydrochloride solution;L-Histdine Dihydrochloride;(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid hydrochloride;(2S)-2-amino-3-(1H-imidazol-5-yl)propionic acid hydrochloride | | CAS: | 1007-42-7 | | MF: | C6H10ClN3O2 | | MW: | 191.62 | | EINECS: | 213-754-2 | | Product Categories: | | | Mol File: | 1007-42-7.mol |  |
| | L-Histidine hydrochloride Chemical Properties |
| Melting point | 240-245 °C (dec.) | | alpha | [α]D20 +7.0～+10.0°(c=2,HCl) | | storage temp. | Inert atmosphere,Room Temperature | | CAS DataBase Reference | 1007-42-7(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | RIDADR | UN 1789 8/PG 3 | | WGK Germany | 3 | | F | 3-10 |
| | L-Histidine hydrochloride Usage And Synthesis |
| Purification Methods | The dihydrochloride crystallises from water or aqueous EtOH and is washed with acetone, then diethyl ether. Alternatively convert it to the histidine di-(3,4-dichlorobenzenesulfonate) salt by dissolving 3,4-dichlorobenzenesulfonic acid (1.5g/10mL) in the aqueous histidine solution with warming, and then the solution is cooled in ice. The resulting crystals (m 280o dec) can be recrystallised from 5% aqueous 3,4-dichlorobenzenesulfonic acid, then dried over CaCl2 under vacuum, and washed with diethyl ether to remove Purification of Biochemicals — Amino Acids and Peptides excess reagent. The dihydrochloride can be regenerated by passing the solution through a Dowex-1 (Cl-form) ion-exchange column. The solid is obtained by evaporation of the solution on a steam bath or better in a vacuum. [Greenstein & Winitz, The Amino Acids Vol 3 p 1976 1961, Beilstein 25/16 V 366.] |
| | L-Histidine hydrochloride Preparation Products And Raw materials |
|