穗花杉双黄酮
| 中文名称 | 穗花杉双黄酮 |
|---|---|
| 中文同义词 | 穗花杉双黄酮;穗花双黄酮;AMENTOFLAVONE 穗花杉双黄酮;穗花杉双黄酮(分析标准品);穗花杉双黄酮, 来源于杉木;穗花杉双黄酮(标准品);穗花杉双黄酮,阿曼托黄酮;阿曼托黄酮 |
| 英文名称 | Amentoflavone |
| 英文同义词 | 8-(5-(5,7-dihydroxy-4-oxo-4H-chroMen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chroMen-4-one;DideMethyl-ginkgetinAMentoflavone;2-(4-Hydroxyphenyl)-5,7-dihydroxy-8-[2-hydroxy-5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one;4',5,7-Trihydroxy-8-[2-hydroxy-5-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]flavone;5,7,4',5'',7'',4'''-Hexahydroxy-3',8''-biflavone;8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;3',8''-BIAPIGENIN 4',4''',5,5'',7,7''-HEXAHYDROXY-3''',8-BIFLAVONE;AMentoflavone, froM CunninghaMia lanceolata |
| CAS号 | 1617-53-4 |
| 分子式 | C30H18O10 |
| 分子量 | 538.46 |
| EINECS号 | 000-000-0 |
| 相关类别 | 植提标准品;对照品;植物提取物;中药对照品;标准品;染色剂和染料;标准品-对照品;Flavones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;黄酮;标准品 -中药标准品;分析试剂-标准品;标准品，对照品 |
| Mol文件 | 1617-53-4.mol |
| 结构式 |  |
穗花杉双黄酮 性质
| 熔点 | >300°C (dec.) |
|---|---|
| 沸点 | 910.5±65.0 °C(Predicted) |
| 密度 | 1.656±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,2-8°C |
| 溶解度 | DMSO（轻微）、甲醇（轻微、加热）、吡啶（轻微） |
| 酸度系数(pKa) | 6.01±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 粘黄色 |
| BRN | 380244 |
| 主要应用 | metabolomics vitamins, nutraceuticals, and natural products |
| 化妆品成分功效 | BLEACHING ANTIOXIDANT |
| InChI | 1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H |
| InChIKey | YUSWMAULDXZHPY-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(O)C=C2)OC2=C(C3=CC(C4OC5=CC(O)=CC(O)=C5C(=O)C=4)=CC=C3O)C(O)=CC(O)=C2C(=O)C=1 |
| LogP | 3.492 (est) |
| CAS 数据库 | 1617-53-4(CAS DataBase Reference) |
穗花杉双黄具有抗炎、抗氧化、抗病毒、抗胖瘤、降血糖和扩张血管等多种生物活性，是一种环氧化酶和黄標呤氧化酶抑制刻，同时，它也是一种碟酸醋酶抑制剂其体外对柯萨奇病毒和泡渗病毒型具有良好抑制效果。穗花杉双黄酮 (Amentoflavone) 是一种天然的双黄酮类化合物，具有很多生物活性，包括抗炎、抗氧化、神经保护等作用。
化学性质
黄色结晶粉末，易溶于甲醇，几乎不溶于乙醚，来源于卷柏，杉木枝叶。用途
穗花杉双黄酮具有抗肿瘤、清除自由基、舒张血管、降血糖的作用。用途
一种具有抗病毒和抗炎作用的生物类黄酮。Amentoflavone is a bioflavonoid that has anti-viral and anti-inflammatory properties. The compound has been observed to inhibit the expression of INOS, LPS-induced activation of NFκB p50 (NF-κ B), translocation of p65 by LPS and block IKKα(I-κ B α) degradation in macrophages. Amentoflavone has been shown to up-regulate PPAR-γ and block the induction of COX-2. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site. The compound has demonstrated anti-viral activity against respiratory syncytial virus (RSV), with an IC50 of 5.5 μg/ml. Amentoflavone has also pronounced inhibition at an IC50 = 14.9 +/- 1.9 nM of benzodiazepine binding in vitro.| 提供商 | 语言 |
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