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| | NOGALAMYCIN Basic information |
| | NOGALAMYCIN Chemical Properties |
| Melting point | 195-196° (dec) | | alpha | D25 +425° (c = 0.11 in CHCl3) | | Boiling point | 658.61°C (rough estimate) | | density | 1.2095 (rough estimate) | | refractive index | 1.7650 (estimate) | | storage temp. | 2-8°C | | solubility | DMF: Soluble; DMSO: Soluble; Ethanol: soluble; Methanol: Soluble | | form | A solid | | pka | 7.45 (60% ethanol) | | color | Orange-red solid from MeOH |
| | NOGALAMYCIN Usage And Synthesis |
| Uses | Nogalamycin (cas# 1404-15-5) is a compound useful in organic synthesis. | | Uses | Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation. | | Definition | ChEBI: Nogalamycin is an anthracycline antibiotic isolated from Streptomyces nogalater. It is a DNA intercalator and exhibits anticancer properties. It has a role as an antineoplastic agent, a cardiotoxic agent, a bacterial metabolite and an intercalator. It is a methyl ester, a polyketide, an anthracycline antibiotic, a tertiary amino compound, a monosaccharide derivative, an organic heterohexacyclic compound and a tetrol. | | Biochem/physiol Actions | Anthracyclic antitumor antibiotic. | | Safety Profile | Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx. |
| | NOGALAMYCIN Preparation Products And Raw materials |
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