ChemicalBook > Product Catalog >API >Circulatory system drugs >Antiarrhythmics Drugs >Atenolol

Atenolol

Atenolol Suppliers list
Company Name: Target Molecule Corp
Tel: 781-999-5354
Email: marketing@targetmol.com
Products Intro: Product Name:Atenolol;(RS)-Atenolol;Tenormin;Normiten;Blokium;Blokium
CAS:29122-68-7
Purity:99.92% Package:500 mg;1 g;1 mL * 10 mM (in DMSO) Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:Atenolol
CAS:29122-68-7
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: PI & PI BIOTECH INC.
Tel: 18371201331
Email: Sales@pipitech.com
Products Intro: Product Name:Atenolol
CAS:29122-68-7
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:2-[4-[(2RS)-2-Hydroxy-3-[(propan-2-yl)amino]propoxy]phenyl]acetamide
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Email: bruce@xrdchem.cn
Products Intro: Product Name:Atenolol
Purity:99% Package:1KG;10USD
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Atenolol
CAS:29122-68-7
Purity:98% Package:1KG;1USD

Lastest Price from Atenolol manufacturers

  • Atenolol
  • US $10.00 / g/Bag
  • 2020-06-07
  • CAS:29122-68-7
  • Min. Order: 1KG
  • Purity: Above 99%
  • Supply Ability: 5000kg/month
  • Atenolol
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:29122-68-7
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
Atenolol Basic information
Pharmacological Affects Chemical Property Uses
Product Name:Atenolol
Synonyms:noten;(RS)-ATENOLOL;(RS)-4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]BENZENEACETAMIDE;TENORMIN;tenlol;1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol;2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-acetamid;2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide
CAS:29122-68-7
MF:C14H22N2O3
MW:266.34
EINECS:249-451-7
Product Categories:API;Isotope;TENORMIN;Amines;Aromatics;Other APIs;API's;Adrenoceptor;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical
Mol File:29122-68-7.mol
Atenolol Structure
Atenolol Chemical Properties
Melting point 154°C
Boiling point 409.54°C (rough estimate)
density 1.0807 (rough estimate)
refractive index 1.5110 (estimate)
Fp 2℃
storage temp. Store at RT
solubility H2O: 0.3 mg/mL
pka9.6(at 25℃)
form powder
color white to off-white
Water Solubility 13.5mg/L(25 ºC)
Merck 14,859
InChIKeyMETKIMKYRPQLGS-UHFFFAOYSA-N
CAS DataBase Reference29122-68-7(CAS DataBase Reference)
NIST Chemistry ReferenceAtenolol(29122-68-7)
EPA Substance Registry SystemBenzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]- (29122-68-7)
Safety Information
Hazard Codes Xn,F
Risk Statements 22-36/37/38-20/21/22-36-11
Safety Statements 22-24/25-36-26-36/37-16
RIDADR UN 1648 3 / PGII
WGK Germany 2
RTECS AC3600000
HazardClass IRRITANT
HS Code 29242995
Hazardous Substances Data29122-68-7(Hazardous Substances Data)
ToxicityLD50 in mice, rats (mg/kg): 2000, 3000 orally; 98.7, 59.24 i.v. (Fitzgerald)
MSDS Information
ProviderLanguage
Tenormin English
SigmaAldrich English
Atenolol Usage And Synthesis
Pharmacological AffectsAtenolol ,also known as atenolol, Aten Yue Er, tamoxifen, downhill Ling blood pressure, Tenormin, blood pressure Ling, is a long-acting cardioselective β1-adrenergic blockers, without intrinsic sympathomimetic activity or membrane stability.The atenolol,s retardation for β1 adrenaline receptors is similar with metoprolol, propranolol and nadolol , which is 1/6 times for pindolol and timolol. But, it does not inhibit the effect of the isoproterenol bronchodilator.When administered in small doses, it does not like non-selective β-adrenergic blockers as aggravated hypoglycemia induced hypertensive crisis, peripheral circulatory impairment or patients with obstructive airways disease worsening airway function and so on. However, When administered in large doses, atenolol also can decrease asthma or chronic obstructive pulmonary disease, airway function. Atenolol, as a long-term treatment of hypertension, also were reported for affecting airway function. Thus, despite atenolol heart selection, chronic obstructive pulmonary disease patients can only use small doses, but also should be given a sufficient amount of β1-adrenergic receptor agonists.
Oral F is 46%~60%, Tmax about 2~4 h, Mainly unchanged since the urine excretion, T1/2 of 6~7 h. Hemodialysis can clear the goods. Rapidly absorbed from the gastrointestinal tract, but not exclusively.The rest of the body is excreted in the stool. Food can reduce the F, fasting and after meals AUC decreased by 20%. Distribution of the central nervous system is relatively few. The ratio of brain tissue to blood concentration was 0.1:1. Easy to achieve in the placenta and the maternal plasma concentrations of same. PPB is less than 5%, Vd is 50~75 L. Atenolol is not metabolized by the liver, most of the drug is excreted from the body in urine, renal insufficiency in patients with T1/2 was significantly prolonged. Patients with renal failure range of T1/2 was 10~28 h, or even up to 100 h. Results at 24 h after, the discharge from the urine of the drug can be reduced by 29%. The T1/2 of patients with hyperthyroidism was significantly shortened, 4.2h.
The above information is edited by the chemicalbook of Kui Ming.
Chemical PropertyWhite powder. Melting point (146-148 ℃). Soluble in alcohol, slightly soluble in water, chloroform, Hardly soluble in ethyl ether, slightly smelly.
Usesβ-blockers. Clinical application in the treatment of hypertension, angina and arrhythmia.
Chemical PropertiesWhite or almost white powder.
OriginatorTenormin,Stuart,UK,1976
UsesSelective b1 adrenergic receptor agonist, anti-hypertensive, anti-anginal, anti-arrhythmic
DefinitionChEBI: An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.
Manufacturing Process1 gram of 1-p-carbamoylmethylphenoxy-2,3-epoxypropane and 10 ml of isopropylamine in 25 ml of methanol is heated in a sealed tube at 110°C for 12 hours. The mixture is evaporated to dryness and the residue is partitioned between 50 ml of chloroform and 50 ml of aqueous 2 N hydrochloric acid. The aqueous acidic layer is separated, made alkaline with sodium carbonate and extracted twice with 50 ml of chloroform each time. The combined extracts are dried and evaporated to dryness and the residue is crystallized from ethyl acetate. There is thus obtained 1-p-carbamoylmethyiphenoxy-3- isopropylamino-2-propanol, MP 146-148°C.
The 1-p-carbamoylmethylphenoxy-2,3-epoxypropane used as starting material may be obtained as follows: a mixture of 3.2 grams of phydroxyphenylacetamide, 25 ml of epichlorohydrin and 6 drops of piperidine is heated at 95-100°C for 6 hours. The mixture is cooled and filtered and the solid product is crystallized from methanol. There is thus obtained 1-pcarbamoylmethylphencxy- 2,3-epoxypropane, MP 158-160°C.
Brand nameTenormin (AstraZeneca).
Therapeutic FunctionBeta-adrenergic blocker
Biological ActivityCardioselective β -adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.
Veterinary Drugs and TreatmentsAtenolol may be useful in the treatment of supraventricular tachyarrhythmias, premature ventricular contractions (PVC’s, VPC’s), systemic hypertension and in treating cats with hypertrophic cardiomyopathy. Atenolol is relatively safe to use in animals with bronchospastic disease.
MetabolismRoughly half of an orally administered dose of atenolol (Tenormin) is absorbed.The drug is eliminated primarily by the kidney and unlike propranolol, undergoes little hepatic metabolism. Its plasma half-life is approximately 6 hours, although if it is administered to a patient with impaired renal function, its half-life can be considerably prolonged.
Atenolol Preparation Products And Raw materials
Raw materials4'-Hydroxyacetophenone-->Isopropylamine-->Epichlorohydrin-->4-Hydroxyphenylacetamide
Tag:Atenolol(29122-68-7) Related Product Information
ATENOLOL MM(CRM STANDARD) ATENOLOL IMP. B (EP): 2-[4-(2,3-DIHYDROXYPROPOXY)PHENYL]ACETAMIDE MM(CRM STANDARD) S(-)-ATENOLOL >96% ACTIVE ENANTIOMER OF,S(-)-ATENOLOL ATENOLOL IMPURITY F ATENOLOL, [RING-3H]- R(+)-ATENOLOL LESS ACTIVE ENANTIOME,(R)-(+)-ATENOLOL ATENOLOL-D7 (ISO-PROPYL-D7) Atenolol 2-HYDROXYACETAMIDE AMINO ACIDS Methoxydiethylborane p-(2-Methoxyethyl) phenol Betaine CHLOROPHOSPHONAZO III ALTRENOGEST Glycine Thioacetamide Acetamide