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Piperidine

Piperidine Chemical Properties
Melting point -11 °C
Boiling point 106 °C(lit.)
density 0.930 g/mL at 20 °C
vapor density 3 (vs air)
vapor pressure 23 mm Hg ( 20 °C)
refractive index n20/D 1.452(lit.)
FEMA 2908 | PIPERIDINE
Fp 16 °C(lit.)
storage temp. Store in dark!
pka11.123(at 25℃)
Water Solubility Miscible
Sensitive Air Sensitive
Merck 14,7468
BRN 102438
Stability:Stable. Highly flammable. Incompatible with strong oxidizing agents, strong acids, organic acids, water. Vapours may flow along surfaces to a distant source of ignition.
CAS DataBase Reference110-89-4(CAS DataBase Reference)
NIST Chemistry ReferencePiperidine(110-89-4)
EPA Substance Registry SystemPiperidine(110-89-4)
Safety Information
Hazard Codes T,F
Risk Statements 61-10-20/21-34-23/24-11-52-24-20/22
Safety Statements 53-16-26-36/37/39-45-27
RIDADR UN 3286 3/PG 2
WGK Germany 3
RTECS TM3500000
3-34
TSCA Yes
HazardClass 8
PackingGroup I
HS Code 29333210
Hazardous Substances Data110-89-4(Hazardous Substances Data)
ToxicityLD50 orally in rats: 0.52 ml/kg (Smyth)
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Piperidine Usage And Synthesis
Chemical PropertiesClear or slightly yellow liquid
UsesFits Applied Biosystems 431 and 433A peptide synthesizers.
UsesPiperidine is an organic heterocyclic amine widely used as building block and reagent in the synthesis of organic compounds including pharmaceuticals.
DefinitionChEBI: An azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. It is a metabolite of cadaverine, a polyamine found in the human intestine.
General DescriptionA clear colorless liquid with a pepper-like odor. Less dense than water, but miscible in water. Will float on water. Flash point 37°F. Melting point -15.8°F (-9°C). Boiling point 222.8°F (106°C). May severely irritate skin and eyes. May be toxic by ingestion and inhalation. Vapors heavier than air. Used to make rubber and as a solvent.
Air & Water ReactionsHighly flammable. Miscible in water.
Reactivity Profile1-Oxa-4-azacyclohexane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health HazardStrong local irritant and may cause permanent injury after short exposure to small amounts. Ingestion may involve both irreversible and reversible changes. 30 to 60 mg/kg may cause symptoms in humans.
Fire Hazard1-Oxa-4-azacyclohexane evolves explosive concentrations of vapor at normal room temperatures. When heated to decomposition, 1-Oxa-4-azacyclohexane emits highly toxic fumes of nitrogen oxides. Dangerous, when exposed to heat, flame, or oxidizers. Avoid 1-Perchloryl1-Oxa-4-azacyclohexane and oxidizing materials. 1-Oxa-4-azacyclohexane is a reactive compound and forms complexes with the salts of heavy metals. 1-Oxa-4-azacyclohexane evolves explosive concentrations of vapor at normal room temperatures. Keep away from igniting sources and heat.
Purification MethodsDry piperidine with BaO, KOH, CaH2, or sodium, and fractionally distil (optionally from sodium, CaH2, or P2O5). Purify from pyridine by zone melting. [Beilstein 22 H 6, 22
Piperidine Preparation Products And Raw materials
Preparation Products3-CYANO-7-METHOXYCOUMARIN-->3-(4-AMINO-PHENYL)-CHROMEN-2-ONE-->7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER-->2-Chloro-6-methyl-3-pyridinecarbonitrile-->6-BROMO-3-BUTYRYL-2H-CHROMEN-2-ONE-->3-(3-AMINOPHENYL)-2H-CHROMEN-2-ONE-->5-METHYL-4-ISOXAZOLESULFONYL CHLORIDE-->2-Amino-5-nitropyrimidine-->Minoxidil-->Bis(pentamethylene)thiuram tetrasulfide -->CLOPERASTINE-->3-ACETAMIDOCOUMARIN-->5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]-PYRIMIDIN-4-ONE-->RARECHEM AL BI 0736-->3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4-->6-CHLORO-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID-->4-Hydroxy-3,5-dimethoxycinnamic acid-->3-ACETYL-7-HYDROXY-2H-CHROMEN-2-ONE-->trans-2,4,5-Trimethoxycinnamic acid-->Difenidol hydrochloride-->5-BROMO-2-FLUOROCINNAMIC ACID-->4-ETHOXYCINNAMIC ACID-->1-PIPERIDINEPENTANOL-->1,2,3,5-TETRAHYDRO-8-THIA-5,7-DIAZA-CYCLOPENTA[A]INDENE-4-ONE-->7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER-->3-(TRIFLUOROMETHOXY)CINNAMIC ACID-->4-Fluorocinnamic acid-->3,5-DIMETHOXYCINNAMIC ACID-->3,4-(Methylenedioxy)cinnamic acid-->2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER-->2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER-->3,5-Dimethoxy-4-hydroxybenzaldehyde-->N-(2-Aminoethyl)piperidine-->NAPHTHALENE-2,3-DICARBOXALDEHYDE-->2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE-->3-(3-METHYL-2-THIENYL)ACRYLIC ACID-->ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE-->2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER-->Tolperisone hydrochloride-->Benproperine phosphate
Raw materialsSodium-->Hydrogen-->Piperidine hydrochloride
Tag:Piperidine(110-89-4) Related Product Information
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