L-半胱亚磺酸
| 中文名称 | L-半胱亚磺酸 |
|---|---|
| 中文同义词 | L-半胱亚磺酸;3-亚磺基-L-丙氨酸;L-半胱氨酸亚磺酸;Α-氨基-Β-亚磺基丙酸;乙酰半胱氨酸杂质25;L-半系八碱酸;乙酰半胱氨酸杂质26 |
| 英文名称 | L-CYSTEINESULFINIC ACID |
| 英文同义词 | L-CYSTEINESULFINIC ACID;CYSTEINE(L) SULFINIC ACID;2-amino-3-sulfino-propanoic acid;3-sulphino-L-alanine;L-cysteine sulphinic acid;L-CYSTEINESULFINIC ACID 1-HYDRATE;Carbocysteine Impurity 5;L-Alanine, 3-sulfino- |
| CAS号 | 1115-65-7 |
| 分子式 | C3H7NO4S |
| 分子量 | 153.16 |
| EINECS号 | 214-228-5 |
| 相关类别 | Amino AcidNeurotransmitters;Excitatory Amino Acids;Metabolic Pathways;Metabolites and Cofactors on the Metabolic Pathways Chart;Others |
| Mol文件 | 1115-65-7.mol |
| 结构式 |  |
L-半胱亚磺酸 性质
| 熔点 | >130°C (dec.) |
|---|---|
| 沸点 | 492.8±55.0 °C(Predicted) |
| 密度 | 1.828±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 酸水溶液（微溶，超声处理），水（微溶） |
| 酸度系数(pKa) | 2.30±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble to 100 mM in water |
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mGluR1 3.92 (pEC 50 ) |
mGluR2 3.9 (pEC 50 ) |
mGluR4 2.7 (pEC 50 ) |
mGluR5 4.6 (pEC 50 ) |
mGluR6 4.0 (pEC 50 ) |
mGluR8 3.94 (pEC 50 ) |
Human Endogenous Metabolite
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L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC 50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing.
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英文
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