| Company Name: |
Aikon International Limited
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| Tel: |
025-58851090 13611564524 |
| Email: |
lwan@aikonchem.com |
| Products Intro: |
CAS:1904651-39-3
Purity:95% Package:5G;10G;100G
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| | Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)- Basic information |
| Product Name: | Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)- | | Synonyms: | Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)-;7-(Difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline;7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-1,2,3,4-tetrahydroquinoline;7-(dif luoromethyl)-6-(1 -methyl-1 H-pyrazol-4-y1)-1,2,3,4-tetrahydroquinoline | | CAS: | 1904651-39-3 | | MF: | C14H15F2N3 | | MW: | 263.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1904651-39-3.mol |  |
| | Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)- Chemical Properties |
| Boiling point | 440.6±45.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | solubility | Dichloromethane; Ethyl Acetate; Methanol | | pka | 3.96±0.20(Predicted) | | form | Solid | | color | Off-White |
| | Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)- Usage And Synthesis |
| Uses | 7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-1,2,3,4-tetrahydroquinoline is an intermediate in the synthesis of GNE-781 (D447825), a derivative of a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology. |
| | Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)- Preparation Products And Raw materials |
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