Company Name: |
ShangHai Biochempartner Co.,Ltd
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Tel: |
177-54423994 17754423994 |
Email: |
2853530910@QQ.com |
Products Intro: |
Product Name:MS48107 CAS:2375070-79-2 Purity:98% HPLC LCMS Package:100MG;1G
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Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- manufacturers
- ms48107
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- $34.00 / 1mg
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2024-11-19
- CAS:2375070-79-2
- Min. Order:
- Purity: 99.5%
- Supply Ability: 10g
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| Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- Basic information |
Product Name: | Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- | Synonyms: | Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro-;MS?48107;Inhibitor,GPR68,GPCR,MS 48107,ms48107,brain-penetrant,BBB,inhibit,5-HT2B,MS-48107,bioavailable;(2-(4-Amino-6-((4-phenoxybenzyl)amino)-1,3,5-triazin-2-yl)-3-fluorophenyl)methanol;ms48107, 10 mM in DMSO | CAS: | 2375070-79-2 | MF: | C23H20FN5O2 | MW: | 417.44 | EINECS: | | Product Categories: | | Mol File: | 2375070-79-2.mol | ![Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- Structure](CAS/20200611/GIF/2375070-79-2.gif) |
| Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- Chemical Properties |
Boiling point | 686.2±65.0 °C(Predicted) | density | 1.366±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : 100 mg/mL (239.56 mM; Need ultrasonic) | form | Solid | pka | 13.91±0.10(Predicted) | color | White to off-white |
| Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- Usage And Synthesis |
Uses | MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can readily cross the blood-brain barrier (BBB) in mice[1]. | in vivo | For MS48107 (compound 71), a single intraperitoneal injection at the dose of 25 mg/kg leads to high exposure levels (above 10 μM) in both plasma and brain at 0.5 h in mice (Swiss Albino mice). The high compound exposure levels in both plasma and brain are maintained for 2 h[1]. | References | [1] Xufen Yu, et al. Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68). J Med Chem. 2019 Aug 22;62(16):7557-7574. DOI:10.1021/acs.jmedchem.9b00869 |
| Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- Preparation Products And Raw materials |
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