Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)-

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Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)- Suppliers list

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Products Intro:	CAS:2356229-14-4 Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G

Company Name:	Wuhan Jingkang en Biomedical Technology Co., Ltd
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Products Intro:	Product Name:Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)- CAS:2356229-14-4 Purity:0.98 Package:10G:100G

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Products Intro:	Product Name:(S)-N-[2-(4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl)ethyl]-N-isopropylmethanesulfonamide CAS:2356229-14-4 Purity:98% Package:1g;10g

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Products Intro:	Product Name:Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)- CAS:2356229-14-4 Purity:98% Package:1g;10g;100g

Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)- Basic information

Product Name:	Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)-
Synonyms:	Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)-;Belotecan-Ms;(S)-N-[2-(4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-11-yl)ethyl]-N-isopropylmethanesulfonamide;T01-1;N-[2-[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0211.0??.01?2o]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]ethyl]-N-isopropyl-methanesulfonamide
CAS:	2356229-14-4
MF:	C26H29N3O6S
MW:	511.59
EINECS:
Product Categories:
Mol File:	2356229-14-4.mol

Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)- Chemical Properties

Boiling point	848.0±75.0 °C(Predicted)
density	1.45±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C, protect from light
form	Solid
pka	11.24±0.20(Predicted)
color	Off-white to yellow
InChIKey	PGWIUEMZGPWFBB-SANMLTNESA-N
SMILES	CS(N(CCC1C2C(N=C3C4N(C(=O)C5COC(=O)[C@@](CC)(O)C=5C=4)CC3=1)=CC=CC=2)C(C)C)(=O)=O

Safety Information

MSDS Information

Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)- Usage And Synthesis

Uses

T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity[1].

in vivo

T01-1 (1 mg/kg; i.v.; single) shows T_1/2 values of 2.78 and 1.97 h in female and male rats, respectively^[1].

Animal Model:

Sprague Dawley rat (half male and half female)^[1].

Dosage:

1 mg/kg

Administration:

Intravenous injection; single

Result:

1.19Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat ^[1].

	IV (1 mg/kg)
	Female	Male
AUC_Last (ng/mL?h)	437	214
C_max (ng/mL)	838	625
MRT_INF (h)	2.81	0.44
T_1/2 (h)	2.78	1.97
T_max (h)	0.08	0.08

References

[1] Li Deliang, et al. Camptothecin derivative and water-soluble prodrug, pharmaceutical composition preparation method, and application. Patent WO2020156189A1.

Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)- Preparation Products And Raw materials

Tag:Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)-(2356229-14-4) Related Product Information

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Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)-

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