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| | L(+)-Ornithine hydrochloride Basic information |
| | L(+)-Ornithine hydrochloride Chemical Properties |
| Melting point | 245 °C (dec.)(lit.) | | alpha | 24 º (c=4, 6N HCl) | | density | 1.57 | | FEMA | 4190 | L-ORNITHINE MONOCHLOROHYDRATE/ORNITHINE | | refractive index | 24 ° (C=4, 6mol/L HCl) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | H2O: 100 mg/mL | | form | Powder | | color | White | | PH | 5.0-6.0 (25℃, 1M in H2O) | | Odor | at 100.00 %. mild green bark | | Odor Type | green | | optical activity | [α]20/D +23.0±0.5°, c = 5% in 5 M HCl | | Water Solubility | Soluble in water (543 mg/ml at 20°C), and alcohol. | | λmax | λ: 260 nm Amax: 0.06
λ: 280 nm Amax: 0.06 | | JECFA Number | 2120 | | Merck | 14,6874 | | BRN | 3625847 | | Stability: | Stable. | | InChIKey | GGTYBZJRPHEQDG-WCCKRBBISA-N | | LogP | -4.22 | | CAS DataBase Reference | 3184-13-2(CAS DataBase Reference) | | EPA Substance Registry System | L-Ornithine, monohydrochloride (3184-13-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-36 | | Safety Statements | 24/25-37/39-26 | | WGK Germany | 3 | | RTECS | RM2985000 | | F | 3-10 | | TSCA | Yes | | HS Code | 29224995 | | Toxicity | LD50 orl-rat: 10 g/kg JPMSAE 62,49,73 |
| | L(+)-Ornithine hydrochloride Usage And Synthesis |
| Chemical Properties | White powder; mild green bark aroma. | | Chemical Properties | L(+)-Ornithine hydrochloride is white crystalline powder | | Uses | L(+)-Ornithine hydrochloride is a nonprotein amino acid used in the biosynthesis of L-arginine, L-proline and polyamines. | | Uses | L(+)-Ornithine hydrochloride is a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L(+)-Ornithine hydrochloride is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta. | | Uses | Non-essential amino acid for human development but is required intermediate in arginine biosynthesis. Found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta. | | Aroma threshold values | Low strength odor, green type. | | Taste threshold values | Very mild sweet taste at 500.00 ppm in water. | | General Description | L-Ornithine is the functional metabolite of L-arginine. | | Flammability and Explosibility | Not classified | | Biochem/physiol Actions | L-ornithine acts as a precursor for polyamines. It may modulate the intake of food as an acute satiety signal in the neonatal chick brain. | | Safety Profile | Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and HCl. | | Purification Methods | Likely impurities are citrulline, arginine and D-ornithine. Crystallise the monohydrochloride from water by adding 4volumes of EtOH and dry it in a vacuum desiccator over fused CaCl2. [Rivard Biochemical Preparations 3 98 1955.] The dihydrochloride [6211-16-1] has m 202-203o and [ ] D +18.4o (c 2.3, 6N HCl) after recrystallisation from MeOH/Et2O [Zaoral & Rudinger Collect Czech Chem Commun 24 2009 1959]. [Beilstein 4 IV 2644.] |
| | L(+)-Ornithine hydrochloride Preparation Products And Raw materials |
| Raw materials | Butanoic acid, 4-cyano-2-[(diphenylmethylene)amino]-, 1,1-dimethylethyl ester, (2S)--->Butanoic acid, 2-amino-4-cyano-, 1,1-dimethylethyl ester, (2S)- (9CI)-->L-Ornithine, 1,1-dimethylethyl ester | | Preparation Products | 3-Methoxy-2-Piperidone-->(2S)-5-amino-2-(tert-butoxycarbonylamino)-pentanoic acid tert-butyl ester-->3-hydroxypiperidin-2-one-->4-aminobutyronitrile-->(S)-3-aminopiperidin-2-one Hydrochloride-->Fmoc-Orn(Boc)-OH |
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