Clemizole

Clemizole Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: Product Name:Clemizole
CAS:442-52-4
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:clemizole
CAS:442-52-4
Purity:99% Package:5KG;1KG Remarks:C19H20ClN3
Company Name: career henan chemical co
Tel: 0086-371-86658258
Email: factory@coreychem.com
Products Intro: Product Name:Clemizole
CAS:442-52-4
Purity:99% Package:1KG;1USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel:
Email: 1010@dideu.com
Products Intro: Product Name:Clemizole
CAS:442-52-4
Purity:99% Package:1g;1USD|10g;1USD|100g;1USD|1KG;1USD|25KG;1USD
Company Name: Target Molecule Corp
Tel: 781-999-5354
Email: marketing@targetmol.com
Products Intro: Product Name:Clemizole
CAS:442-52-4
Purity:98.65% Package:5 mg;10 mg;50 mg;100 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

Lastest Price from Clemizole manufacturers

  • Clemizole
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:442-52-4
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • Clemizole
  • US $1.00 / KG
  • 2020-01-03
  • CAS:442-52-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200kg
Clemizole Basic information
Product Name:Clemizole
Synonyms:Clemizole (free base);1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole (Clemizole);1-(4-Chlorobenzyl)-2-(pyrrolizinomethyl)-1H-benzimidazole;1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole;Histacur;1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)benzimidazole;1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole;1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole
CAS:442-52-4
MF:C19H20ClN3
MW:325.84
EINECS:207-133-5
Product Categories:Inhibitors;API intermediates
Mol File:442-52-4.mol
Clemizole Structure
Clemizole Chemical Properties
Melting point 239-241℃
Safety Information
MSDS Information
Clemizole Usage And Synthesis
OriginatorAllercur,Roerig,US,1960
DefinitionChEBI: A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.
Manufacturing ProcessFrom 13.1 g of N-p-chlorobenzyl-2-nitroaniline (MP 110°C, obtained in the form of orange-red needles, from o-nitrochlorobenzene and pchlorobenzylamine by reaction for 3 hours at 150°C) by reduction with Raneynickel and hydrogen, in which reaction the substance may be suspended in methanol or dissolved in methanol-ethyl acetate at normal pressure and at about 40°C with combination of the theoretical quantity of hydrogen, 12.2 g are obtained of o-amino-N-p-chlorobenzylaniline, which after recrystallization from aqueous methanol has a MP of 90°C.
8 g of o-amino-N-p-chlorobenzylaniline and 2.8 g of pyridine are dissolved in dry ether and reacted with an ethereal solution of 3.9 g of chloracetyl chloride with cooling in a mixture of ice and common salt. 8 g of N-p-chlorobenzyl-N'- chloracetyl-o-phenylene diamine are obtained which can be worked up in the form of the crude product and, in the slightly colored form, has a MP of 130°C.
7.6 g of this compound are boiled with 3.9 g of pyrrolidine in 70 cc of toluene for some hours under reflux. After extraction by shaking with water and treatment with hydrochloric acid the hydrochloride is produced of N-pchlorobenzyl-N'-pyrrolidylacetyl-o-phenylene diamine together with some 1-pchlorobenzyl-2-N-pyrrolidylmethyl-benzimidazole. The former, after recrystallization from butanol, melts with foaming at 205°C, the latter, after recrystallization from butanol melts at 239°C to 241°C, and is in the form of white microscopic rods. Boiling in nitrobenzene converts the former compound into the latter.
Therapeutic FunctionAntihistaminic
Tag:Clemizole(442-52-4) Related Product Information
N-Ethylbenzimidazole (1-BENZYL-1H-IMIDAZOL-2-YL)METHYLAMINE,97% C-(1-ETHYL-1H-IMIDAZOL-2-YL)-METHYLAMINE ETHYL-(1-METHYL-1 H-IMIDAZOL-2-YLMETHYL)-AMINE Chlormidazole CHEMBRDG-BB 4014415 1,2Dimethylbenzimidazole 1H-IMIDAZOL-2-YLMETHYLAMINE DIHYDROCHLORIDE 2-(PYRROLIDIN-1-YLMETHYL)-1H-IMIDAZOLE C-(1-BENZYL-1H-BENZOIMIDAZOL-2-YL)-METHYLAMINE 1-METHYLBENZIMIDAZOLE 1-Benzyl-2-methyl-1H-imidazole Benzylpenicillinclemizole 2-AMINOMETHYLIMIDAZOLE HYDROCHLORIDE Clemizole TIMTEC-BB SBB000240 METHYL-(1-METHYL-1H-IMIDAZOL-2-YLMETHYL)-AMINE (1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE