| Company Name: |
Sigma-Aldrich
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Product Name:Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt
CAS:185246-32-6
Purity:>=98% (HPLC), powder Package:5MG Remarks:B6684-5MG
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| Company Name: |
EMMX Biotechnology LLC
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888-539-0666 |
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info@emmx.com |
| Products Intro: |
Product Name:Rp-8-Br-PET-cGMPS
CAS:185246-32-6
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE manufacturers
- Rp-8-Br-PET-cGMPS
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- $668.00 / 1mg
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2025-07-26
- CAS:185246-32-6
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Basic information |
| Product Name: | RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE | | Synonyms: | RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE;Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3μ:5μ-cyclic monophosphorothioate hydrate sodium salt;Rp-8-Br-PET-cGMPS hydrate, Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3μ,5μ-cyclic monophosphorothioate hydrate sodium salt;Rp-8-bromo-PET-Cyclic GMPS (sodium salt);Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate;Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt;Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt >=98% (HPLC), powder;Rp-8-bromo-PET-Cyclic GMPS sodium | | CAS: | 185246-32-6 | | MF: | C18H14BrN5NaO6PS | | MW: | 562.266 | | EINECS: | | | Product Categories: | | | Mol File: | 185246-32-6.mol |  |
| | RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Chemical Properties |
| Melting point | 240-300 °C(lit.) | | storage temp. | -20°C | | solubility | H2O: soluble15mg/mL at ≤60°C | | form | powder | | color | white to beige | | Water Solubility | H2O: 15mg/mL at≤60°C |
| | RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Usage And Synthesis |
| Description | Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM). It less potently inhibits protein kinase A (Ki = 11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 = 25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki = 1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11. | | Uses | Rp-8-Br-PET-cyclic GMPS Sodium Salt is a competitive inhibitor of cGMP-dependent protein kinase (cGKI). | | Biochem/physiol Actions | Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki?=?30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50?=?25 micromoles). | | storage | Store at -20°C | | References | [1] E BUTT. Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS.[J]. British Journal of Pharmacology, 1995, 116 8: 3110-3116. DOI: 10.1111/j.1476-5381.1995.tb15112.x
[2] NADEJDA VALTCHEVA. The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells.[J]. The Journal of Biological Chemistry, 2009, 284 1: 556-562. DOI: 10.1074/jbc.m806161200
[3] JI-YE WEI. Identification of Competitive Antagonists of the Rod Photoreceptor cGMP-Gated Cation Channel: β-Phenyl-1,N2-etheno-Substituted cGMP Analogues as Probes of the cGMP-Binding Site?[J]. Biochemistry Biochemistry, 1996, 35 51: 16815-16823. DOI: 10.1021/bi961763v
[4] RONALD J?GER. Activation of PDE10 and PDE11 phosphodiesterases.[J]. The Journal of Biological Chemistry, 2012: 1210-1219. DOI: 10.1074/jbc.m111.263806 |
| | RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Preparation Products And Raw materials |
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