| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
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| Tel: |
0571-87213919 |
| Email: |
Eric@peptidego.com |
| Products Intro: |
Product Name:Elamipretide Acetate
CAS:1334953-95-5
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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MTP 131 acetate manufacturers
- MTP 131 acetate
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- $0.00 / 1removed
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2025-09-18
- CAS:1334953-95-5
- Min. Order:
- Purity: 99.90%
- Supply Ability: 10g
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| | MTP 131 acetate Basic information |
| | MTP 131 acetate Chemical Properties |
| storage temp. | -20°C | | solubility | PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid |
| | MTP 131 acetate Usage And Synthesis |
| Biological Activity | MTP 131 is a mitochondria-targeted peptide antioxidant.1,2 It localizes to the mitochondria and reduces tert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 nM.1 MTP 131 (2 mg/kg) reduces infarct volume, hemispheric swelling, and glutathione (GSH) depletion in a mouse model of acute cerebral ischemia induced by middle cerebral artery occlusion (MCAO).2 It increases survival, improves motor function, and decreases degeneration of the lumbar spinal cord in a superoxide dismutase 1 mutant (SOD1G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 5 mg/kg. MTP 131 reduces albuminuria, urinary hydrogen peroxide levels, and mesangial matrix accumulation, as well as preserves superoxide production, in a db/db mouse model of diabetic nephropathy.3 | | References | 1.Zhao, K., Luo, G., Giannelli, S., et al.Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell linesBiochem. Pharmacol.70(12)1796-1806(2005)
2.Szeto, H.H.Mitochondria-targeted peptide antioxidants: Novel neuroprotective agentsAAPS J.8(3)E521-E531(2006)
3.Miyamoto, S., Zhang, G., Hall, D., et al.Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney diseaseJ. Biol. Chem.295(21)7249-7260(2020) |
| | MTP 131 acetate Preparation Products And Raw materials |
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