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| | INDEX NAME NOT YET ASSIGNED Basic information |
| | INDEX NAME NOT YET ASSIGNED Chemical Properties |
| Boiling point | 1240.1±65.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | pka | 13.10±0.70(Predicted) |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| Description | SHP2-D26 is a first, potent, and effective PROTAC degrader of SHP2 protein. SHP2-D26 achieves DC50 values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, respectively, and is capable of reducing SHP2 protein levels by >95% in cancer cells. SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines. |
| | INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
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