| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PNU-107484A
CAS:200266-76-8
Package:100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600
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9H-Pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine, 9-methyl-2,4-di-1-pyrrolidinyl-, hydrochloride (1:1) manufacturers
- PNU-107484A
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- $2500.00 / 100mg
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2025-08-21
- CAS:200266-76-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 9H-Pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine, 9-methyl-2,4-di-1-pyrrolidinyl-, hydrochloride (1:1) Basic information |
| Product Name: | 9H-Pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine, 9-methyl-2,4-di-1-pyrrolidinyl-, hydrochloride (1:1) | | Synonyms: | 9H-Pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine, 9-methyl-2,4-di-1-pyrrolidinyl-, hydrochloride (1:1) | | CAS: | 200266-76-8 | | MF: | C18H23ClN6 | | MW: | 358.87 | | EINECS: | | | Product Categories: | | | Mol File: | 200266-76-8.mol | ![9H-Pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine, 9-methyl-2,4-di-1-pyrrolidinyl-, hydrochloride (1:1) Structure](CAS/20211123/GIF/200266-76-8.gif) |
| | 9H-Pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine, 9-methyl-2,4-di-1-pyrrolidinyl-, hydrochloride (1:1) Chemical Properties |
| | 9H-Pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine, 9-methyl-2,4-di-1-pyrrolidinyl-, hydrochloride (1:1) Usage And Synthesis |
| Uses | PNU-107484A is a GABAA receptor ligand that exhibits target activity mechanisms dependent on α isoforms. In the α1β2γ2 subtype, PNU-107484A acts as a positive allosteric modulator, enhancing GABA-induced Cl- currents, while it inhibits the currents in the α3β2γ2 and α6β2γ2 subtypes. The half-maximal concentrations for the α1β2γ2, α3β2γ2, and α6β2γ2 subtypes are 3.1, 4.2, and 3.5 μM, respectively. PNU-107484A can be used as a probe to investigate the physiological roles of different α isoform subtypes[1]. | | References | [1] Im HK, et al. PNU-107484A with alpha isoform-dependent functional changes in alpha(x)beta2gamma2 subtypes of rat recombinant GABA(A) receptors. Br J Pharmacol. 1997 Nov;122(5):821-4. DOI:10.1038/sj.bjp.0701450 |
| | 9H-Pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine, 9-methyl-2,4-di-1-pyrrolidinyl-, hydrochloride (1:1) Preparation Products And Raw materials |
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