| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:NMK-TD-100
CAS:1252802-38-2
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
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NMK-TD 100 manufacturers
- NMK-TD-100
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- $1980.00 / 50mg
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2024-10-28
- CAS:1252802-38-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | NMK-TD 100 Basic information |
| | NMK-TD 100 Chemical Properties |
| | NMK-TD 100 Usage And Synthesis |
| Description | NMK-TD-100 is a novel microtubule modulating agent. NMK-TD-100 blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin. Polymerization of tissue purified tubulin into microtubules was inhibited by NMK-TD-100 with an IC50 value of 17.5±0.35 μM. The binding of NMK-TD-100 to tubulin was estimated to be ~10 times faster than that of colchicine. NMK-TD-100 exerted anti-proliferative activity by disrupting microtubule functions through tubulin binding and provided insights into its potential of being a chemotherapeutic agent. | | Uses | NMK-TD-100 is a modulator for microtubule. NMK-TD-100 binds to tubulin, inhibits the tubulin polymerization with an IC50 of 17.5 μM, inhibits mitosis, and decreases mitochondrial membrane potential (MMP). NMK-TD-100 inhibits the proliferation of HeLa with an IC50 of 1.42 μM, arrests cell cycle at G2/M phase, induces apoptosis in HeLa[1]. | | References | [1] Bhattacharya S, et al., NMK-TD-100, a novel microtubule modulating agent, blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin. PLoS One. 2013 Oct 7;8(10):e76286. DOI:10.1371/journal.pone.0076286 |
| | NMK-TD 100 Preparation Products And Raw materials |
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