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Polyoxyethylene stearate

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CAS:9004-99-3
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Polyoxyethylene stearate Basic information
Product Name:Polyoxyethylene stearate
Synonyms:s1004;s1012;s1054;s1116;s541;slovasolmks16;soromin-sg;stabilisantdelta-118
CAS:9004-99-3
MF:(C2H4O)nC18H36O2
MW:622.91
EINECS:618-405-1
Product Categories:Ester Type (Surfactants);Ethylene Glycols & Monofunctional Ethylene Glycols;Functional Materials;Monofunctional Ethylene Glycols;Nonionic Surfactants;Surfactants;solvent;Cosmetic Ingredients & Chemicals;bc0001
Mol File:9004-99-3.mol
Polyoxyethylene stearate Structure
Polyoxyethylene stearate Chemical Properties
Melting point 47 °C
Fp 39 °C
storage temp. 2-8°C
Water Solubility Soluble in water
solubility Chloroform (Slighty), Methanol (Slightly)
form powder to lump
color White to Almost white
Odorat 100.00?%. mild fatty
Hydrophilic-Lipophilic Balance (HLB)18.8
LogP7.629 (est)
EPA Substance Registry SystemPolyethylene glycol monostearate (9004-99-3)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 1
RTECS MD0907300
HS Code 3907200000
Hazardous Substances Data9004-99-3(Hazardous Substances Data)
ToxicityLD50 oral in rabbit: > 12mL/kg
MSDS Information
ProviderLanguage
PEG monostearate English
SigmaAldrich English
Polyoxyethylene stearate Usage And Synthesis
Chemical PropertiesWaxy, light-tan solid; nearly odorless. Congealing range 39–45C. Soluble in water, alcohol, ether, and acetone; insoluble in mineral and vegetable oils.
UsesPolyoxyethylene stearate is an emulsifier and antifoaming agent used in processed foods, fruit jellies, and sauces.
UsesPegosperse(R) 1500 MS is a mixture of polyethylene glycol esters. It is compatible with lipophilic compounds due to a higher free fatty acid content. Suggested applications: cosmetic formulations, lubricants.
Pegosperse(R) 1750 MS is a high molecular weight, high HLB surface active agent suggested for use in cosmetic formulations (emulsifier, viscosity modifier) and lubricants (emulsifier).
Pegosperse(R) 400 MS is a multifunctional surface active agent suggested for use in cosmetic formulations, household products, lubricants, textile chemicals, polishes and paper.
PEG-5 stearate, an emulsifier, is listed as particularly applicable for hand and body lotions and creams.
DefinitionPolyoxyethylene stearate is a mixture of the monoand diesters of stearic acid and mixed polyoxyethylene diols having an average polymer length of 7.5 oxyethylene units.
Brand nameMyrj 53 (ICI Americas).
General DescriptionPolyoxyethylene (40) stearate is a neutral surfactant.
Safety ProfileVery slightly toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also other polyethylene glycol monostearate entries and POLYETHYLENE GLYCOL.
in vitroPolyoxyethylene stearate has been recommended as an additive to the radiolabelled 7H12 Middlebrook TB media and, as such, has been shown to enhance the growth of mycobacteria in the radiometric BACTEC rapid culture system. Polyoxyethylene (50) stearate produces the greatest enhancement in growth and reduction in the time taken to detect growth for M. tuberculosis and polyoxyethylene (30) stearate and polyoxyethylene (JL) stearate for species of mycobacteria other than M. tuberculosis. Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration-dependent manner mainly by modulating substrate-stimulated P-gp ATPase activity. Polyoxyethylene 40 stearate reduces vinblastine sulfate efllux. The cytotoxicity of vinblastine to K562/ADR cells is significantly enhanced when cotreated with 100 or 150 μg/mL polyoxyethylene 40 stearate.
in vivoPolyoxyethylene stearate is potentially useful as a pharmaceutical ingredient to improve the oral bioavailability of coadministered P-gp substrates and substrates for certain CYP isoforms. The average tumour volume and weight are significantly less in the polyoxyethylene 40 stearate+vinblastine groups. The inhibition rate for tumor growth is increased from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group).
Polyoxyethylene stearate Preparation Products And Raw materials
Raw materialsStearic acid-->Polyethylene Glycol-->Glycerol tristearate
Preparation Productsdefoaming agent TS-103
Tag:Polyoxyethylene stearate(9004-99-3) Related Product Information
alkyl phenyl polyoxyethylene ether Diethylene glycol Polyethylene glycol monooleate Polyethylene Glycol Triethylene glycol Polyoxyethylene fatty acid GLYCERYL MONOSTEARATE Glyceryl monostearate Ethylene glycol 2-Methyl-2,4-pentanediol Polyethylene Cremophor EL C8E3 triglycerol stearate ETHYLENE GLYCOL MONOSTEARATE GLYCERYL MONOSTEARATE 1,4-Butanediol PROPYLENE GLYCOL

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