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(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Suppliers list
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J & K SCIENTIFIC LTD.
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Product Name:(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(diMethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexaMethyl-17-(2-Methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid
CAS:193146-26-8
Package:0.1Mg,1Mg
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3B Pharmachem (Wuhan) International Co.,Ltd.
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Product Name:(3S,6R,7S,12Z,15S,16E)-3,7-BIS-([TERT-BUTYL(DIMETHYL)SILYL]OXY)-15-HYDROXY-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXOHEPTADECA-12,16-DIENOIC ACID
CAS:193146-26-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Chemsky（shanghai）International Co.,Ltd.
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Product Name:(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(diMethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexaMethyl-17-(2-Methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid
CAS:193146-26-8
Purity:98%
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
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Product Name:(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(diMethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexaMethyl-17-(2-Methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid
CAS:193146-26-8
Package:Mg Remarks:TRC
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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Product Name:(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(diMethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexaMethyl-17-(2-Methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid
CAS:193146-26-8
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| | (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Basic information |
| Product Name: | (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid | | Synonyms: | (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid;[3S-(3R*,6S*,7R*,8R*,12Z,15R*,16E)]-3,7-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-15-hydr;(3S,6R,7S,8S,12Z,15S,16E)-3,7-bis{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic acid;12,16-Heptadecadienoic acid, 3,7-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-, (3S,6R,7S,8S,12Z,15S,16E)-;Paclitaxel Impurity 72 | | CAS: | 193146-26-8 | | MF: | C39H71NO6SSi2 | | MW: | 738.22 | | EINECS: | | | Product Categories: | Chiral Reagents | | Mol File: | 193146-26-8.mol | ![(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Structure](CAS2/GIF/193146-26-8.gif) |
| | (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Chemical Properties |
| Boiling point | 732.7±60.0 °C(Predicted) | | density | 1.016±0.06 g/cm3(Predicted) | | solubility | Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene | | pka | 4.05±0.10(Predicted) | | form | Oil |
| | (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Usage And Synthesis |
| Chemical Properties | Oil | | Uses | An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
| | (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Preparation Products And Raw materials |
| Preparation Products | (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione |
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