| Company Name: |
Shanghai Boyle Chemical Co., Ltd.
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| Tel: |
021-50182298 021-50180596 |
| Email: |
sales@boylechem.com |
| Products Intro: |
Product Name:4'-Hydroxy TaMoxifen
CAS:82413-23-8
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:4'-Hydroxy TaMoxifen (contains up to 10% E isoMer)
CAS:82413-23-8
Package:2.5Mg,25Mg
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| | 4Hydroxy Tamoxifen Basic information |
| | 4Hydroxy Tamoxifen Chemical Properties |
| Melting point | 150-153°C | | Boiling point | 514.4±50.0 °C(Predicted) | | density | 1.092±0.06 g/cm3(Predicted) | | storage temp. | Amber Vial, -20°C Freezer, Under Inert Atmosphere | | solubility | Chloroform (Slightly), Dichloromethane, Methanol (Slightly) | | form | Solid | | pka | 10.32±0.15(Predicted) | | color | White to Off-White | | Stability: | Light Sensitive |
| | 4Hydroxy Tamoxifen Usage And Synthesis |
| Description | 4’-hydroxy Tamoxifen is one of five main phase I metabolites of tamoxifen , a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. 4’-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity. With the addition of a hydroxyl group, 4’-hydroxy tamoxifen has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. At 10-100 μM, 4’-hydroxy tamoxifen is cytotoxic, in a non-apoptotic manner, to HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines. | | Chemical Properties | White Solid | | Uses | A metabolite of Tamoxifen (T006000). |
| | 4Hydroxy Tamoxifen Preparation Products And Raw materials |
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