| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diamine
CAS:10023-54-8
Package:500mg
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| Company Name: |
Clearsynth Labs Limited
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| Tel: |
+91-22-26355700 |
| Email: |
info@clearsynth.com |
| Products Intro: |
Product Name:N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diaMine
CAS:10023-54-8
Remarks:CS-M-06163
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| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:Aminoquinol
CAS:10023-54-8
Purity:98% HPLC LCMS Package:500mg/;1g/
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| Company Name: |
Wuhan Topule
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| Tel: |
+86-02787215551 +86-19945035818 |
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2936752263@qq.com |
| Products Intro: |
Product Name:Aminoquinol
CAS:10023-54-8
Purity:98% hplc lcms Package:5MG;10MG;50MG;100MG,1G,5G， 5KG;1KG
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| | Aminoquinol Basic information |
| Product Name: | Aminoquinol | | Synonyms: | Aminoquinol;7-Chloro-2-(o-chlorostyryl)-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline;N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diami;N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-dia;N4-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediamine tris(phosphate);1,4-Pentanediamine, N4-[7-chloro-2-[2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-;Aminoquinol
DISCONTINUED. Please see C609759. | | CAS: | 10023-54-8 | | MF: | C26H31Cl2N3 | | MW: | 456.45 | | EINECS: | | | Product Categories: | | | Mol File: | 10023-54-8.mol |  |
| | Aminoquinol Chemical Properties |
| Melting point | 223-225° | | Boiling point | 597.1±50.0 °C(Predicted) | | density | 1.191±0.06 g/cm3(Predicted) | | storage temp. | RT | | solubility | Soluble in DMSO (up to 25 mg/ml with warming). | | form | solid | | pka | 10.47±0.25(Predicted) | | color | Light brown | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | Aminoquinol Usage And Synthesis |
| Description | XIB4035 (10023-54-8) is a novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50?= 10.4 μM. Like GDNF, XIB4035 induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells.1?Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3? GDNF agonists may be a new class of Parkinson’s disease therapeutics.4 | | References | 1) Tokugawa?et al. (2003),?XIB4035, a novel nonpeptidyl small molecule agonist for GFRα-1; Neurochem. Int.,?42?81
2) Hedstrom?et al. (2014),?Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling; Proc. Natl. Acad. Sci. USA,?111?2325
3) Hsieh?et al.?(2018)?Distinct TrkA and Ret modulated negative and positive neuropathic behaviors in a mouse model of resiniferatoxin-induced small fiber neuropathy; Exp. Neurol.?300?87
4) Drinkut?et al.?(2016)?Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in Parkinson disease mouse model; Cell Death Dis.,?7?e2359 |
| | Aminoquinol Preparation Products And Raw materials |
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