Ivabradine

Ivabradine Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:Ivabradine API
CAS:155974-00-8
Purity:99% Package:25KG;5KG;1KG
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name: Ivabradine
CAS:155974-00-8
Purity:98% Package:1KG;1USD
Company Name: HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
Tel: +86-19933070948 +86-19930599843
Email: claire@hbyingong.com
Products Intro: Product Name:Ivabradine
CAS:155974-00-8
Purity:99% Package:1kg;200USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:ivabradine
CAS:155974-00-8
Purity:99% Package:5KG;1KG Remarks:C27H36N2O5
Company Name: Chongqing Chemdad Co., Ltd
Tel: +undefined-86-13650506873 +undefined-86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:Ivabradine
CAS:155974-00-8
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg

Ivabradine manufacturers

  • Ivabradine
  • $200.00 / 1kg
  • 2022-11-29
  • CAS:155974-00-8
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 1000kg/Month
  • Ivabradine USP/EP/BP
  • $1.10 / 1g
  • 2021-08-07
  • CAS:155974-00-8
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
  • ivabradine
  • $15.00 / 1KG
  • 2021-07-02
  • CAS:155974-00-8
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Ivabradine Basic information
Product Name:Ivabradine
Synonyms:3-[3-[[(8S)-3,4-dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methyl-amino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;3-[3-[[(8S)-3,4-dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;Ivabradine;Ivabridine –;7-(3-((((R)-4,5-diMethoxy-1,2-dihydrocyclobutabenzen-1-yl)Methyl)(Methyl)aMino)propyl)-2,3-diMethoxy-8,9-dihydro-5H-benzo[7]annulen-6(7H)-one;Ivabradine(Hydrochloride form);2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-;Ivabradine HCl Premix
CAS:155974-00-8
MF:C27H36N2O5
MW:468.59
EINECS:
Product Categories:API
Mol File:155974-00-8.mol
Ivabradine Structure
Ivabradine Chemical Properties
Boiling point 626.9±55.0 °C(Predicted)
density 1.146±0.06 g/cm3(Predicted)
pka8.77±0.50(Predicted)
Safety Information
MSDS Information
Ivabradine Usage And Synthesis
DescriptionIvabradine is a first selective and specific If inhibitor that was approved by EMEA in November for symptomatic treatment of chronic stable angina pectoris in patients with normal sinus rhythm. This is the first agent to lower heart rate by inhibiting the cardiac pacemaker If current. The compound was discovered and developed by Servier and is currently being marketed in Ireland.
DefinitionChEBI: A member of the class of benzazepines that is 7,8-dimethoxy-1,3,4,5-tetrahydro-3-benzazepin-2-one in which the amide hydrogen is replaced by a [{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl} group. Use (as its hydrochloride salt) to treat patients with angina who have intolerance to beta blockers and/or heart failure.
SynthesisThe convergent synthesis of ivabradine was accomplished by coupling the key benzocylclobutanyl amine 73 with oxadioxalane 76 in an in situ deprotection and amination as shown in Scheme 13. For the synthesis of the key amine 73, cyano group of compound 69 is reduced with borane-THF to give amine 70 in 90% yield, which was reacted with ethyl chloroformate to give carbamate 71 in 80% yield. Complete reduction of the carbamate was accomplished by refluxing with LAH in THF to give racemic methyl amine 72 in 92% yield, which was then resolved by crystallizing with N-acetyl –L-glutamic acid to give chiral salt 73. Prior to the next step, the amine is converted to the hydrochloride salt.
The coupling partner 76 to make ivabradine was prepared from the azepinone 74 by first reacting with bromoethyldioxalane to give 75. The olefin in 75 was reduced by hydrogenating with palladium/carbon catalyst at 55°C to give 76. To the same pot, the amine 73 was added and hydrogenated to give reductive amination product ivabradine hydrochloride (X) in very good yields.

Ivabradine Preparation Products And Raw materials
Tag:Ivabradine(155974-00-8) Related Product Information
Erlotinib hydrochloride Hydroxy Ivabradine Ivabradine Impurity 1 Hydrochloride 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one 7-DeMethyl Ivabradine N-Desmethyl Ivabradine D6 HCl (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Ivabradine hydrochloride N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide Ivabradine Impurity 21 HCl ent-Ivabradine Hydrochloride Ivabradine Impurity 16 HCl C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE Ivabradine IMpurity Ivabradine Impurity 15 Dehydro Ivabradine Oxalate Ivabradine Impurity 1 Hydrochloride