| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
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sales@chemhifuture.com |
| Products Intro: |
Product Name:2435715-90-3
CAS:2435715-90-3
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g
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| | 2435715-90-3 Basic information |
| Product Name: | 2435715-90-3 | | Synonyms: | 2,6-Piperidinedione, 3-[4-(4-aminobutyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:1) | | CAS: | 2435715-90-3 | | MF: | C17H21N3O3.ClH | | MW: | 351.83 | | EINECS: | | | Product Categories: | | | Mol File: | 2435715-90-3.mol |  |
| | 2435715-90-3 Chemical Properties |
| form | Solid | | color | Light yellow to yellow |
| | 2435715-90-3 Usage And Synthesis |
| Uses | Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1]. | | IC 50 | Cereblon | | References | [1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816 |
| | 2435715-90-3 Preparation Products And Raw materials |
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