2435715-90-3

2435715-90-3 Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
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Products Intro: Product Name:Lenalidomide-C4-NH2 (hydrochloride)
CAS:2435715-90-3
Purity:98% Package:1g
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Tel: 13504435624
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Products Intro: Product Name:Lenalidomide-C4-NH2 hydrochloride
CAS:2435715-90-3
Company Name: Shanghai Haohong Pharmaceutical Co., Ltd.  
Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Products Intro: Product Name:Lenalidomide-C4-NH2 (hydrochloride)
CAS:2435715-90-3
Purity:98%
Company Name: Shanghai Tachizaki Biomedical Research Center  
Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Products Intro: Product Name:2435715-90-3
CAS:2435715-90-3
Purity:98%+ HPLC Package:10mg,500mg,1g,2g,5g+
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:2435715-90-3
CAS:2435715-90-3
Purity:98%+ HPLC Package:10mg,500mg,1g,2g,5g,10g
2435715-90-3 Basic information
Product Name:2435715-90-3
Synonyms:2,6-Piperidinedione, 3-[4-(4-aminobutyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:1)
CAS:2435715-90-3
MF:C17H21N3O3.ClH
MW:351.83
EINECS:
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Mol File:2435715-90-3.mol
2435715-90-3 Structure
2435715-90-3 Chemical Properties
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
2435715-90-3 Usage And Synthesis
UsesLenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].
IC 50Cereblon
References[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
2435715-90-3 Preparation Products And Raw materials
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