| Company Name: |
Shanghai Tauto Biotech Co., Ltd.
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| Tel: |
021-51320588 |
| Email: |
tauto@tautobiotech.com |
| Products Intro: |
Product Name:UK-1
CAS:151271-53-3
Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:BVT-0013-M001
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| Product Name: | UK 1 | | Synonyms: | UK 1;UK 1 (cytotoxin);2'-(2-Hydroxyphenyl)-[2,4'-bibenzoxazole]-4-carboxylic acid methyl ester;[2,4'-Bibenzoxazole]-4-carboxylic acid, 2'-(2-hydroxyphenyl)-, methyl ester | | CAS: | 151271-53-3 | | MF: | C22H14N2O5 | | MW: | 386.36 | | EINECS: | | | Product Categories: | | | Mol File: | 151271-53-3.mol |  |
| Melting point | 209-210℃ | | Boiling point | 541.4±30.0 °C(Predicted) | | density | 1.396±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO;Soluble in dimethyl formamide | | form | solid | | pka | 8.55±0.30(Predicted) | | color | White to off-white |
| Uses | UK-1 is an antibiotic and antifungal inhibitor of topoisomerase II. | | Uses | UK-1 is an unusual bis-benzoxazole metabolite isolated from a species of Streptomyces. UK-1 exhibits good antitumour activity but is devoid of antimicrobial activity. UK-1 acts as a magnesium ion-dependent, DNA binding agent and inhibitor of human topoisomerase II. | | Biological Activity | uk 1, an unusual bis-benzoxazole metabolite isolated from streptomyces sp. 517-02, is an inhibitor of topoisomerase ii (topo ii) and hepatitis c viral replication. it is an antifungal and an antibiotic, and displays a wide spectrum of potent anticancer activities against lymphoma, leukemia, and certain solid tumor-derived cell lines with ic50 values as low as 20 nm. however, uk 1 is devoid of antimicrobial activity and is inactive against pseudomonas aeruginosa and staphylococcus aureus, a methicillin-resistant strain of s. aureus. additionally, uk-1 can bind a wide variety of di- and tri-valent metal ions, particularly mg2+ ions, and form complexes with dna in the presence of mg2+ ions. topo ii are atp-dependent enzymes, which can simultaneously cut both strands of the dna helix to manage dna supercoils and tangles. | | in vitro | uk 1 strongly blocked the growth of human epitheloid carcinoma hela, mouse melanoma b16, mouse leukemia p388 cells with ed50 values of 1.22 μg/ml, 1.17 μg/ml, and 0.11 μg/ml, respectively. uk 1 did not display any growth inhibitory activity against bacteria, fungi and yeasts up to 100 μg/ml [1]. | | storage | +4°C | | references | [1]. ueki, m., ueno, k., miyadoh, s., abe, k., shibata, k., taniguchi, m., & oi, s. uk-1, a novel cytotoxic metabolite from streptomyces sp. 517-02. i. taxonomy, fermentation, isolation, physico-chemical and biological properties. the journal of antibiotics. 1993; 46(7): 1089-1094. |
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