- Bruceine A 25514-31-2
-
- $160.00 / 20mg
-
2022-02-14
- CAS:25514-31-2
- Min. Order: 10mg
- Purity: >98% by HPLC
- Supply Ability: 1000.00 kgs
- bruceine A
-
- $2.00 / 1kg
-
2019-07-06
- CAS:25514-31-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
|
| | bruceine A Basic information |
| Product Name: | bruceine A | | Synonyms: | bruceine A;13,20-Epoxy-3,11β,12α-trihydroxy-15β-(3-methyl-1-oxobutoxy)-2,16-dioxopicras-3-en-21-oic acid methyl ester;Dihydrobrusatol;NSC 310616;Bruceine A (Dihydrobrusatol;Bruceine A 25514-31-2;Brucea javanica A;NSC31616 | | CAS: | 25514-31-2 | | MF: | C26H34O11 | | MW: | 522.54 | | EINECS: | | | Product Categories: | | | Mol File: | 25514-31-2.mol |  |
| | bruceine A Chemical Properties |
| Boiling point | 712.6±60.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in EtOH; insoluble in H2O; ≥5.23 mg/mL in DMSO with gentle warming | | form | Powder | | pka | 8.81±0.70(Predicted) |
| | bruceine A Usage And Synthesis |
| Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the fruit of bruce chinensis. | | Uses | Bruceantin A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, also an effective anti-trypanosomal agent in vitro. Cytotoxic agent. | | Definition | ChEBI: Bruceine A is a quassinoid. | | Biological Activity | ic50: 7.7 nm against the parasitescanine babesiosis is a tick-borne disease caused by the intraerythrocytic apicomplexan parasites, babesia gibsoni and b. canis. clinical signs of b. gibsoni infection are anemia, fever, thrombocytopenia, splenomegaly, lymphadenopathy, and lethargy. bruceine a, a natural quassinoid compound extracted from the brucea javanica (l.) merr. dried fruits, was reported to have antibabesial activity. | | Physiological effects | Bruisein A has an effect of treating malignant tumor, antimalarial and anti-inflammatory. | | in vitro | bruceine a inhibited the in-vitro babesia gibsoni growth in canine erythrocytes at lower concentration compared with the antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nm [1]. | | in vivo | oral administration of bruceine a at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog. an untreated dog developed typical acute babesiosis symptoms including high fever, severe anemia, and complete loss of appetite and movement. however, the two bruceine a-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks [1]. | | target | Antifection | p65 | NF-kB | ROS | | references | [1] nakao r, mizukami c, kawamura y, subeki, bawm s, yamasaki m, maede y, matsuura h, nabeta k, nonaka n, oku y, katakura k. evaluation of efficacy of bruceine a, a natural quassinoid compound extracted from a medicinal plant, brucea javanica, for canine babesiosis. j vet med sci. 2009 jan;71(1):33-41. |
| | bruceine A Preparation Products And Raw materials |
|