- 6-Chloroguanine
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- $0.00 / 25Kg/Drum
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2024-09-19
- CAS:10310-21-1
- Min. Order: 100g/Bag
- Purity: 99%
- Supply Ability: 100mt/year
- 2-Amino-6-chloropurine
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- $5.00 / 1KG
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2024-09-19
- CAS:10310-21-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000kg
- 6-Chloroguanine
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- $0.00 / 25Kg/Drum
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2024-09-18
- CAS:10310-21-1
- Min. Order: 1KG
- Purity: 99%min
- Supply Ability: 10 TONS
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| 6-Chloroguanine Chemical Properties |
Melting point | >300 °C (lit.) | Boiling point | 279.76°C (rough estimate) | density | 1.4937 (rough estimate) | refractive index | 1.6110 (estimate) | storage temp. | 2-8°C | solubility | Solubility in 1mol/L NaOH | form | Powder | pka | 6.65±0.20(Predicted) | color | White to yellow | Water Solubility | 1.7 g/L (20 ºC) | BRN | 9626 | InChI | InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11) | InChIKey | RYYIULNRIVUMTQ-UHFFFAOYSA-N | SMILES | N1C2C(=NC(N)=NC=2Cl)NC=1 | CAS DataBase Reference | 10310-21-1(CAS DataBase Reference) | EPA Substance Registry System | 6-Chloro-2-aminopurine (10310-21-1) |
Hazard Codes | Xi,Xn | Risk Statements | 20/21/22-36/37/38 | Safety Statements | 22-24/25-36-26 | WGK Germany | 3 | RTECS | UO7502000 | F | 10 | Hazard Note | Irritant/Keep Cold | HazardClass | IRRITANT, KEEP COLD | HS Code | 29339900 |
| 6-Chloroguanine Usage And Synthesis |
Description | 6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.
| Description | 2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6). | Chemical Properties | white to light yellow crystal powder | Uses | 2-Amino-6-chloropurine may be used:
- in the enzymatic synthesis of 2′-deoxyguanosine
- in the synthesis of 9-alkyl purines
- in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases
| Uses | 2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. | Definition | ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound. | General Description | 2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method. | Synthesis | Preparation of 2-amino-6-chloropurine: Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield). |
| 6-Chloroguanine Preparation Products And Raw materials |
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