- Afatinib impurity 76
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- $0.00 / 10mg
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2025-03-04
- CAS:
- Min. Order: 10mg
- Purity: 98%
- Supply Ability: 500mg
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| | 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Basic information |
| Product Name: | 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- | | Synonyms: | 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-;4-(3-chloro-4-fiuoro-phen...;N-(3-chloro-4-fluorophenyl)-N-(7-fluoro-6-nitroquinazolin-4-yl)acetaMide;(3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine;Afatinib intermediate A;3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl);N-(3-chloro-4-fluorophenyl)-7-fiuoro-6-nitro-4-quinazolinaMine;N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine | | CAS: | 162012-67-1 | | MF: | C14H7ClF2N4O2 | | MW: | 336.68 | | EINECS: | 000-000-0 | | Product Categories: | API intermediates;162012-67-1 | | Mol File: | 162012-67-1.mol |  |
| | 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Chemical Properties |
| Melting point | 242-244℃ | | Boiling point | 489℃ | | density | 1.616 | | Fp | 249℃ | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | form | Solid | | pka | 5.07±0.70(Predicted) | | color | Yellow to Dark Yellow |
| | 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Usage And Synthesis |
| Uses | 4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. |
| | 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Preparation Products And Raw materials |
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