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TERBUTALINE SULFATE

TERBUTALINE SULFATE Suppliers list
Company Name: Biopole Pharmatech Co., Ltd.
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Products Intro: Product Name:Terbutaline sulfate
Purity:99.99%HPLC Package:1g
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
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Products Intro: Product Name:TERBUTALINE SULFATE
CAS:23031-32-5
Purity:0.99 Package:1KG;150.00;USD|10KG;1500.00;USD
Company Name: airuikechemical co., ltd.
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Products Intro: Product Name:Terbutaline sulfate
CAS:23031-32-5
Purity:99.9% Package:1g;|5g;|25g
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
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Products Intro: Product Name:TIANFU-CHEM -TERBUTALINE SULFATE
CAS:23031-32-5
Purity:99% Package:25KG;5KG;1KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008657128800458; +8615858145714
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Products Intro: Product Name:TERBUTALINE SULFATE
CAS:23031-32-5
Purity:as in COA Package:as customers' requirements

TERBUTALINE SULFATE manufacturers

  • Terbutaline sulfate
  • Terbutaline sulfate pictures
  • $0.00 / 1g
  • 2024-03-11
  • CAS:23031-32-5
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 20tons
  • Terbutaline sulfate
  • Terbutaline sulfate pictures
  • $0.00 / 1g
  • 2024-02-06
  • CAS:2563300
  • Min. Order: 1g
  • Purity: 99.99%HPLC
  • Supply Ability: 200kg
TERBUTALINE SULFATE Basic information
Product Name:TERBUTALINE SULFATE
Synonyms:1-(3,5-dihydroxyphenyl)-2-tert-butylaminoethanolsulphate;3-benzenediol,5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-sulfate(2;alpha-((tert-butylamino)methyl)-3,5-dihydroxybenzylalcoholsulfate(2:1)(sa;alpha-((tert-butylamino)methyl)-3,5-dihydroxy-benzylalcohosulfate(2:1);Bricanyl[R];2-tert-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, Brethaire, Brethine, Butaliret, Monovent, Terbasmin, Terbul;TERBASMIN;TERBUTALINE SULFATE
CAS:23031-32-5
MF:C24H40N2O10S
MW:548.65
EINECS:245-386-3
Product Categories:BRETHAIRE;Intermediates & Fine Chemicals;Pharmaceuticals;Active Pharmaceutical Ingredients
Mol File:23031-32-5.mol
TERBUTALINE SULFATE Structure
TERBUTALINE SULFATE Chemical Properties
Melting point 246-248°C
density 1.1840 (rough estimate)
refractive index 1.6900 (estimate)
storage temp. 2-8°C
solubility H2O: soluble100mg/mL, clear to slightly hazy, colorless to yellow
pkapKa1 8.8, pKa2 10.1, pKa3 11.2(at 25℃)
color White to Off-White
InChIInChI=1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)
InChIKeyKFVSLSTULZVNPG-UHFFFAOYSA-N
SMILESC1(=CC(=CC(O)=C1)O)C(O)CNC(C)(C)C.C1(=CC(=CC(O)=C1)O)C(O)CNC(C)(C)C.S(=O)(=O)(O)O
Safety Information
Hazard Codes Xn
Risk Statements 42/43-63
Safety Statements 26-36
WGK Germany 3
RTECS DN9000000
HS Code 2922504500
Toxicitydog,LD50,intravenous,116mg/kg (116mg/kg),Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 757, 1972.
MSDS Information
ProviderLanguage
SigmaAldrich English
TERBUTALINE SULFATE Usage And Synthesis
DescriptionTerbutaline is the N-t-butyl analogue of metaproterenol and, as such, would be expected to have a more potent β2-selectivity. When compared to metaproterenol, terbutaline has a threefold greater potency at the β2-receptor. Like metaproterenol, it is resistant to COMT and slowly metabolized by MAO, therefore having good oral bioavailability with similar onset and duration. Terbutaline is available as tablets and solutions for injection and inhalation. Adverse effects are similar to other direct-acting β2-selective agonists, however, with a greater incidence of palp
DescriptionTerbutaline (hemisulfate) (Item No. 21292) is an analytical reference standard categorized as a β2-adrenergic receptor agonist. Terbutaline has been used to enhance physical performance in athletes. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .
Chemical PropertiesWhite or almost white, crystalline powder.
OriginatorBricanyl,Pharma-Stern,W. Germany,1971
UsesAnti Asthmatic
Usesbetaadrenergic agonist, bronchodilator
UsesTerbutaline Sulfate is derived from the starting material, Terbutaline Hemisulfate Salt (T109750), which is a β-adrenergic receptor agonist. A Bronchodilator; Metabolite of Terbutaline (T109763).
UsesA B-Adrenergic receptor agonist. A Bronchodilator
DefinitionChEBI: Terbutaline sulfate is an ethanolamine sulfate salt. It is functionally related to a terbutaline.
Manufacturing ProcessTo a solution of 32 g of benzyl-t-butylamine in 300 ml of absolute ethanol at reflux temperature was added 32 g of 3,5-dibenzyloxy-?-bromoacetophenone in 10 ml of dry benzene. The mixture was refluxed for 20 hours and then evaporated. When absolute ether was added to the residue, benzyl-tbutylamine hydrobromide was precipitated. The precipitated compound was filtered off and to the filtrate was added an excess of 2 N sulfuric acid. This caused precipitation of the hydrogen sulfate of 3,5-dibenzyloxy-?-(benzyl-tbutylamino)- acetophenone which was recrystallized from acetone/ether. If the product is crystallized from different organic solvents, the melting point will vary with the type and amount of solvent of crystallization, but the product can be used directly for hydrogenation.
15 g of 3,5-dibenzyloxy-?-(benzyl-t-butylamino)-acetophenone hydrogen sulfate in 200 ml of glacial acetic acid were hydrogenated in a Parr pressure reaction apparatus in the presence of 1.5 g of 10% palladium charcoal at 50°C and 5 atmospheres pressure. The reaction time was 5 hours. The catalyst was filtered off, the filtrate was evaporated to dryness and the hydrogen sulfate of 1-(3',5'-dihydroxyphenyl)-2-(t-butylamino)-ethanol was received. This compound is hygroscopic, but it can be transformed into a nonhygroscopic sulfate in the following manner.
The hydrogen sulfate was dissolved in water and the pH of the solution was adjusted to 5.6 (pH-meter) with 0.1 N sodium hydroxide solution. The water solution was evaporated to dryness and the residue dried with absolute ethanol/benzene and once more evaporated to dryness. The remaining crystal mixture was extracted in a Soxhlet extraction apparatus with absolute methanol. From the methanol phase the sulfate of 1-(3',5'-dihydroxyphenyl)- 2-(t-butylamino)-ethanol crystallized. Melting point 246°C to 248°C.
Brand nameTerbutaline is INN and BAN.
Therapeutic FunctionBronchodilator
Clinical UseBeta2 -adrenoceptor agonist:
Reversible airways obstruction
Veterinary Drugs and TreatmentsTerbutaline is used as a bronchodilating agent in the adjunctive treatment of cardiopulmonary diseases (including tracheobronchitis, collapsing trachea, pulmonary edema, and allergic bronchitis) in small animals. It may be of some benefit in treating bradyarrhythmias in dogs and cats.
Terbutaline has been used occasionally in horses for its bronchodilating effects, but adverse effects, short duration of activity after IV administration and poor oral absorption have limited its use. It has been shown to be useful as a diagnostic agent to diagnose anhidrosis in horses after intradermal injection.
Oral and intravenous terbutaline has been used successfully in humans for the inhibition of premature labor clinical signs.
Drug interactionsPotentially hazardous interactions with other drugs
Effect may be diminished by beta-blockers.
Theophylline: increased risk of hypokalaemia.
MetabolismTerbutaline undergoes extensive first-pass metabolism by sulphate (and some glucuronide) conjugation in the liver and the gut wall. It is excreted in the urine and faeces partly as the inactive sulphate conjugate and partly as unchanged terbutaline, the ratio depending upon the route by which it is given.
TERBUTALINE SULFATE Preparation Products And Raw materials
Raw materialsGovernment regulation-->Palladium-->Sodium borohydride-->Benzyl bromide-->tert-Butylamine-->3,5-Dihydroxyacetophenone-->Hydrogen
Tag:TERBUTALINE SULFATE(23031-32-5) Related Product Information
Levalbuterol Related Compound B (20 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-methyl-benzenemethanol) 2-(tert-butylamino)-1-(4-ethoxy-3-(hydroxymethyl)phenyl)ethanol 4-tert-ButylaMinoethyl-2-Methylphenol Levalbuterol Related Compound E (30 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-3-(ethoxy-methyl)-4-hydroxy-benzenemethanol) Entacapone Salbutamol Ipratropium bromide monohydrate 1-[2,5-bis(benzyloxy)phenyl]ethan-1-one BECLOMETHASONE Ipratropium bromide Montelukast sodium (r)-budesonide Budesonide 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol H-89 DIHYDROCHLORIDE HYDRATE ZSTK474 4-Benzyl Albuterol Salbutamol Related Compound 1