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TERBUTALINE SULFATE

TERBUTALINE SULFATE Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
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Products Intro: Product Name:TERBUTALINE SULFATE
CAS:23031-32-5
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: CAS:23031-32-5
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hangzhou FandaChem Co.,Ltd.
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Products Intro: Product Name:TERBUTALINE SULFATE
CAS:23031-32-5
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Company Name: career henan chemical co
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Products Intro: Product Name:TERBUTALINE SULFATE
CAS: 23031-32-5
Purity:99% Package:1KG;7USD
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:TERBUTALINE SULFATE
CAS:23031-32-5
Purity:99% Package:1kg

TERBUTALINE SULFATE manufacturers

  • Terbutaline Sulfate
  • $0.00-0.00 / Kg/Drum
  • 2021-09-29
  • CAS:23031-32-5
  • Min. Order: 1KG
  • Purity: 98%-101%; BP
  • Supply Ability: 100KGS
  • TERBUTALINE SULFATE
  • $15.00-10.00 / KG
  • 2021-07-02
  • CAS:23031-32-5
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
TERBUTALINE SULFATE Basic information
Product Name:TERBUTALINE SULFATE
Synonyms:1-(3,5-dihydroxyphenyl)-2-tert-butylaminoethanolsulphate;3-benzenediol,5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-sulfate(2;alpha-((tert-butylamino)methyl)-3,5-dihydroxybenzylalcoholsulfate(2:1)(sa;alpha-((tert-butylamino)methyl)-3,5-dihydroxy-benzylalcohosulfate(2:1);bricanyl;Bricanyl[R];2-tert-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, Brethaire, Brethine, Butaliret, Monovent, Terbasmin, Terbul;TERBASMIN
CAS:23031-32-5
MF:C24H40N2O10S
MW:548.65
EINECS:245-386-3
Product Categories:BRETHAIRE;Intermediates & Fine Chemicals;Active Pharmaceutical Ingredients;Pharmaceuticals
Mol File:23031-32-5.mol
TERBUTALINE SULFATE Structure
TERBUTALINE SULFATE Chemical Properties
Melting point 246-248°C
density 1.1840 (rough estimate)
refractive index 1.6900 (estimate)
storage temp. 2-8°C
solubility H2O: soluble100mg/mL, clear to slightly hazy, colorless to yellow
pkapKa1 8.8, pKa2 10.1, pKa3 11.2(at 25℃)
form neat
InChIKeyKFVSLSTULZVNPG-UHFFFAOYSA-N
Safety Information
Hazard Codes Xn
Risk Statements 42/43-63
Safety Statements 26-36
WGK Germany 3
RTECS DN9000000
HS Code 2922504500
MSDS Information
ProviderLanguage
SigmaAldrich English
TERBUTALINE SULFATE Usage And Synthesis
DescriptionTerbutaline is the N-t-butyl analogue of metaproterenol and, as such, would be expected to have a more potent β2-selectivity. When compared to metaproterenol, terbutaline has a threefold greater potency at the β2-receptor. Like metaproterenol, it is resistant to COMT and slowly metabolized by MAO, therefore having good oral bioavailability with similar onset and duration. Terbutaline is available as tablets and solutions for injection and inhalation. Adverse effects are similar to other direct-acting β2-selective agonists, however, with a greater incidence of palp
Chemical PropertiesWhite or almost white, crystalline powder.
OriginatorBricanyl,Pharma-Stern,W. Germany,1971
Usesbetaadrenergic agonist, bronchodilator
UsesAnti Asthmatic
UsesA B-Adrenergic receptor agonist. A Bronchodilator
Manufacturing ProcessTo a solution of 32 g of benzyl-t-butylamine in 300 ml of absolute ethanol at reflux temperature was added 32 g of 3,5-dibenzyloxy-?-bromoacetophenone in 10 ml of dry benzene. The mixture was refluxed for 20 hours and then evaporated. When absolute ether was added to the residue, benzyl-tbutylamine hydrobromide was precipitated. The precipitated compound was filtered off and to the filtrate was added an excess of 2 N sulfuric acid. This caused precipitation of the hydrogen sulfate of 3,5-dibenzyloxy-?-(benzyl-tbutylamino)- acetophenone which was recrystallized from acetone/ether. If the product is crystallized from different organic solvents, the melting point will vary with the type and amount of solvent of crystallization, but the product can be used directly for hydrogenation.
15 g of 3,5-dibenzyloxy-?-(benzyl-t-butylamino)-acetophenone hydrogen sulfate in 200 ml of glacial acetic acid were hydrogenated in a Parr pressure reaction apparatus in the presence of 1.5 g of 10% palladium charcoal at 50°C and 5 atmospheres pressure. The reaction time was 5 hours. The catalyst was filtered off, the filtrate was evaporated to dryness and the hydrogen sulfate of 1-(3',5'-dihydroxyphenyl)-2-(t-butylamino)-ethanol was received. This compound is hygroscopic, but it can be transformed into a nonhygroscopic sulfate in the following manner.
The hydrogen sulfate was dissolved in water and the pH of the solution was adjusted to 5.6 (pH-meter) with 0.1 N sodium hydroxide solution. The water solution was evaporated to dryness and the residue dried with absolute ethanol/benzene and once more evaporated to dryness. The remaining crystal mixture was extracted in a Soxhlet extraction apparatus with absolute methanol. From the methanol phase the sulfate of 1-(3',5'-dihydroxyphenyl)- 2-(t-butylamino)-ethanol crystallized. Melting point 246°C to 248°C.
Brand nameTerbutaline is INN and BAN.
Therapeutic FunctionBronchodilator
Veterinary Drugs and TreatmentsTerbutaline is used as a bronchodilating agent in the adjunctive treatment of cardiopulmonary diseases (including tracheobronchitis, collapsing trachea, pulmonary edema, and allergic bronchitis) in small animals. It may be of some benefit in treating bradyarrhythmias in dogs and cats.
Terbutaline has been used occasionally in horses for its bronchodilating effects, but adverse effects, short duration of activity after IV administration and poor oral absorption have limited its use. It has been shown to be useful as a diagnostic agent to diagnose anhidrosis in horses after intradermal injection.
Oral and intravenous terbutaline has been used successfully in humans for the inhibition of premature labor clinical signs.
TERBUTALINE SULFATE Preparation Products And Raw materials
Raw materialsGovernment regulation-->Palladium-->Sodium borohydride-->Benzyl bromide-->tert-Butylamine-->3,5-Dihydroxyacetophenone-->Hydrogen
Tag:TERBUTALINE SULFATE(23031-32-5) Related Product Information
BECLOMETHASONE Budesonide Ipratropium bromide monohydrate Entacapone Salbutamol 1-[2,5-bis(benzyloxy)phenyl]ethan-1-one Ipratropium bromide Montelukast sodium (r)-budesonide 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol H-89 DIHYDROCHLORIDE HYDRATE ZSTK474 Terbutaline sulfate BP Bambuterol hydrochloride TERBUTALINE SULFATE