|
|
| | AMINOPEPTIDASE M Basic information |
| Product Name: | AMINOPEPTIDASE M | | Synonyms: | AMINO ACID ARYLAMIDASE;AMINOPEPTIDASE M;AMINOPEPTIDASE M, 20 UNITS;AMINOPEPTIDASE (MICROSOMAL);AMINOPEPTIDASE M, PORCINE KIDNEY;AMINOPEPTIDASE M TYPE IV-S;AMINOPEPTIDASE M TYPE VI;AMINOPEPTIDASE M TYPE VI-S | | CAS: | 9054-63-1 | | MF: | C12H24O2 | | MW: | 0 | | EINECS: | 232-942-5 | | Product Categories: | | | Mol File: | Mol File | ![AMINOPEPTIDASE M Structure]() |
| | AMINOPEPTIDASE M Chemical Properties |
| storage temp. | 2-8°C | | form | powder | | color | white |
| | AMINOPEPTIDASE M Usage And Synthesis |
| Uses | Leucine Aminopeptidase, microsomal from porcine kidney has been used in aminopeptidase N (APN) inhibitor screening assay in adenocarcinoma cell line ES-2 and in the inhibition kinetic studies with APN inhibitor. | | Uses | Transforming Growth Factor-β1 (TGF-β) human has been used :
- to study the expression of PDGFRB (Platelet derived growth factor receptor β) in association with transforming growth factor-β signaling.
- to stimulate lung fibrosis in human fetal lung fibroblast cell line in order to further measure the in-plane elasticity of live cell layers using a pressure sensor embedded microfluidic device.
- to study the effect of TGF-β on HTRA1 (high-temperature requirement A1)-affected Wnt target genes.
| | General Description | The biologically active form of TGF-β1 (transforming growth factor-β1 human) exists as a disulphide-linked homodimer. In mammals, three isoforms of TGF-β has been identified : TGF-β1, TGF-β2 and TGF-β3. TGF-β1 encodes a 25 kDa peptide. TGF-β1 precursor polypeptide is characterized with hydrophobic signal sequence, pro-region and mature peptide. Cleavage of the precursor at tetrabasic cleavage site results in monomers of carboxy-terminal 112 amino acids. The TGF-β1 gene is mapped to human chromosome 19q13.2. | | Biochem/physiol Actions | TGF-β1 is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2. |
| | AMINOPEPTIDASE M Preparation Products And Raw materials |
|