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| [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Basic information |
Product Name: | [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- | Synonyms: | [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-;ISCK03;SteM-Cell Factor/c-Kit Inhibitor, ISCK03;[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide;Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl];ISCK 03; ISCK-03;4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide;Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem | CAS: | 945526-43-2 | MF: | C19H21N3O2S | MW: | 355.45 | EINECS: | | Product Categories: | API | Mol File: | 945526-43-2.mol | |
| [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Chemical Properties |
storage temp. | Sealed in dry,2-8°C | solubility | Soluble in ethanol or DMSO | form | solid | color | yellow | Sensitive | Light Sensitive | InChIKey | XQABBHBFHWHMKF-UHFFFAOYSA-N |
Hazard Codes | Xi | Risk Statements | 36 | Safety Statements | 26 | WGK Germany | 1 |
| [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Usage And Synthesis |
Uses | Inhibits in vitro phosphorylation of c-Kit. Also inhibits SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells | Biological Activity | isck03 is an inhibitor of scf-mediated c-kit activation.the signaling downstream of scf/c-kit plays a key role in the development of various mammalian cells, such as mast cells, melanocytes, primordial germ cells, and hematopoietic progenitor cells. | in vitro | previous study showed that the pretreatment of 501mel cells with isck03 could dose-dependently inhibit scf-induced c-kit phosphorylation. isck03 could also inhibit the phosphorylation of p44/42 erk mitogen-activated protein kinase that was known to be involved in scf/c-kit downstream signaling. however, isck03 was not able to inhibit hepatocyte growth factor-induced phosphorylation of p44/42 erk proteins [1]. | in vivo | to determine the in vivo efficacy, isck03was orally administered to depilated c57bl/6 mice. results showed that the oral administration of isck03 could induce the dose-dependent depigmentation of newly regrown hair, and this was reversed with cessation of isck03 treatment. in addition, the topical application of isck03 could promote the depigmentation of uv-induced hyperpigmented spots on n brownish guinea pig skin. moreover, the fontana–masson staining analyses showed epidermal melanin was diminished in spots treated with isck03 [1]. | references | [1] y. j. na, h. s. baek, s. m. ahn, et al. [4-t-butylphenyl]-n-(4-imidazol-1-yl phenyl)sulfonamide (isck03) inhibits scf/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. biochemical pharmacology 74(5), 780-786 (2007). |
| [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Preparation Products And Raw materials |
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