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(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

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(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Suppliers list
Company Name: sgtlifesciences pvt ltd
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Products Intro: Product Name:Atenolol R-Isomer
CAS:56715-13-0
Company Name: Alfa Chemistry
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Products Intro: Product Name:(R)-(+)-Atenolol
CAS:56715-13-0
Purity:99%
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
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Products Intro: Product Name:(R)-(+)-Atenolol
CAS:56715-13-0
Purity:NLT 98% Remarks:MC560883
Company Name: China National Standard Pharmaceutical Corporation Limited
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Products Intro: Product Name:Atenolol Impurity 15 ((R)-Atenolol)
CAS:56715-13-0
Purity:0.95 Package:Vials
Company Name: Aladdin Scientific
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Products Intro: Product Name:(R)-Atenolol
CAS:56715-13-0
Purity:99% Package:$55.9/5mg;$75.9/10mg;$123.9/25mg;$173.9/50mg;$243.9/100mg;Bulk package Remarks:99%
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Basic information
Product Name:(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
Synonyms:4-[(R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide;2-[4-[(2R)-2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide;2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide;2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethanamide;(R)-(+)-Atenolol,(+)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide;R(+)-ATENOLOL LESS ACTIVE ENANTIOME;Benzeneacetamide, 4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-;Benzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, (R)-
CAS:56715-13-0
MF:C14H22N2O3
MW:266.34
EINECS:
Product Categories:Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:56715-13-0.mol
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Structure
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Chemical Properties
Melting point 148-152 °C(lit.)
Boiling point 508.0±50.0 °C(Predicted)
density 1.125±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >6.0 mg/mL
pka13.88±0.20(Predicted)
form solid
color pale yellow
optical activity[α]25/D +16°, c = 1 in 1 M HCl
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Usage And Synthesis
Description(+)-Atenolol is an enantiomer of the β1-adrenergic receptor (β1-AR) antagonist (±)-atenolol . (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (Ki = 8.61 μM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats.
Usesless active enantiomer
UsesAntihypertensor
UsesCardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
DefinitionChEBI: The (R)-enantiomer of atenolol.
references[1] stoschitzky k, egginger g, zernig g, et al. stereoselective features of (r)- and (s)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[j]. chirality, 1993, 5(1): 15-19.
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Preparation Products And Raw materials
Raw materialsAtenolol-->S(-)-ATENOLOL-->4-Hydroxyphenylacetamide-->4-Hydroxyphenylacetic acid-->Isopropylamine
Tag:(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE(56715-13-0) Related Product Information
S(-)-ATENOLOL (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Atenolol 4-Hydroxyphenylacetamide 4-METHOXYPHENYLACETAMIDE 1-AMINO-3-PHENOXY-PROPAN-2-OL 3-(4-methylphenoxy)propan-1-amine CHEMBRDG-BB 5482082 (2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL AKOS BC-1949 4-(3-Amino-2-hydroxypropoxy)phenylacetamide 3-(ISOPROPYLAMINO)-1,2-PROPANEDIOL 1-AMINO-3-(4-ETHYLPHENOXY)PROPAN-2-OL (R)-3-ISOPROPYLAMINO-1,2-PROPANEDIOL 1-METHYLAMINO-3-PHENOXY-PROPAN-2-OL CHEMBRDG-BB 9070877 ATENOLOL IMPURITY STANDARD