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| | ANTIBIOTIC UCN-02 Basic information |
| Product Name: | ANTIBIOTIC UCN-02 | | Synonyms: | UCN-02;ANTIBIOTIC UCN-02;9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3S,9S,10R,11R,13R)-;UCN02,UCN 02 | | CAS: | 121569-61-7 | | MF: | C28H26N4O4 | | MW: | 482.53 | | EINECS: | | | Product Categories: | | | Mol File: | 121569-61-7.mol |  |
| | ANTIBIOTIC UCN-02 Chemical Properties |
| Boiling point | 705.7±60.0 °C(Predicted) | | density | 1.63±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | solution in ethanol. | | pka | 12.25±0.70(Predicted) |
| | ANTIBIOTIC UCN-02 Usage And Synthesis |
| Description | UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01 first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC50 = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells. | | Uses | UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing?Streptomyces?culture. Related analogs of staurosporine which is non-specific protein kinase inhibitor. | | Uses | UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms. | | references | [1] takahashi, i. ,saitoh, y.,yoshida, m., et al. ucn-01 and ucn-02, new selective inhibitors of protein kinase c. ii. purification, physico-chemical properties, structural determination and biological activities. j.antibiot.(tokyo) 42(4), 571-576 (1989).
[2] newton a c. protein kinase c: structure, function, and regulation[j]. journal of biological chemistry, 1995, 270(48): 28495-28498. |
| | ANTIBIOTIC UCN-02 Preparation Products And Raw materials |
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