- UCPH-101
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- $1.00 / 1g
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2019-12-25
- CAS:1118460-77-7
- Min. Order: 1g
- Purity: 99.99%
- Supply Ability: 200kg
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| | UCPH-101 Basic information |
| Product Name: | UCPH-101 | | Synonyms: | UCPH-101;2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile;4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-;2-Amino-4-(4-methoxy-phenyl)-7-naphthalen-1-yl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;UCPH-101; UCPH 101; UCPH101;CS-2757;2-amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;inhibit,UCPH101,UCPH-101,Inhibitor | | CAS: | 1118460-77-7 | | MF: | C27H22N2O3 | | MW: | 422.48 | | EINECS: | | | Product Categories: | Glutamate | | Mol File: | 1118460-77-7.mol |  |
| | UCPH-101 Chemical Properties |
| Melting point | 194.0-197.2 °C | | Boiling point | 703.5±60.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Soluble in DMSO (up to 10 mg/ml). | | form | solid | | pka | 3.23±0.60(Predicted) | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| | UCPH-101 Usage And Synthesis |
| Description | UCPH-101 is a noncompetitive inhibitor of excitatory amino acid transporter 1 (EAAT1), which takes up extracellular glutamate in the central nervous system. UCPH-1 is selective for EAAT1 over EAAT2 and EAAT3 with IC50 values of 0.66, >300, and >300 μM, respectively, in a radioligand uptake assay using HEK293 cells transfected with the human transporter. It selectively inhibits anion currents in tsA201 cells expressing human EAAT1 (Kd = 0.34 μM) over rat EAAT4 and mouse EAAT5 at concentrations up to 10 μM. UCPH-101 is orally bioavailable in rats at a dose of 10 mg/kg but does not cross the blood-brain barrier. | | Uses | UCPH 101 is a subtype-selective inhibitor of human excitatory amino acid transporter subtype 1. | | storage | Store at +4°C | | References | 1) Jensen?et al.?(2009),?Discovery of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1; J. Med. Chem.,?52?912
2) Erichsen?et al.?(2010),?Structure-Activity Relationship Study of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101); J. Med. Chem.,?53?7180
3) Corbetta?et al.?(2019),?Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma; Int. J. Cancer,?144?2539 |
| | UCPH-101 Preparation Products And Raw materials |
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