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N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide

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N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide Suppliers list
Company Name: TargetMol Chemicals Inc.
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Email: marketing@targetmol.com
Products Intro: Product Name:VU0155069；CAY10593
CAS:1130067-06-9
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Siyang Liaoning Biochemical Products Co. Ltd
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Products Intro: Product Name:(S)-WAY 100135 dihydrochloride
CAS:1130067-06-9
Purity:>98% Package:1kg;5kg;20kg;25kg
Company Name: Zhejiang J&C Biological Technology Co.,Limited
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Products Intro: Product Name:VU0155069
CAS:1130067-06-9
Purity:99% Package:5KG;1KG Remarks:VU0155069
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
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Products Intro: Product Name:VU-0155069
CAS:1130067-06-9
Purity:98% Package:10mg Remarks:V24392
Company Name: Henan Allgreen Chemical Co.,LTD
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Products Intro: Product Name:N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benziMidazol-1-yl)-1-piperidinyl]-1-Methylethyl-2-naphthalenecarboxaMide CAY10593 VU 0155069
CAS:1130067-06-9
Purity:99% Package:1kg,5kg,25kg,50kg,200kg
N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide Basic information
Product Name:N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide
Synonyms:N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide;VU 0155069;(S)-N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide;2-Naphthalenecarboxamide, N-[(1S)-2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-;N-[1-[4-(5-CHLORO-2-OXO-3H-BENZIMIDAZOL-1-YL)PIPERIDIN-1-YL]PROPAN-2-YL]NAPHTHALENE-2-CARBOXAMIDE;CAY10593 (VU0155069);CS-2781;N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benziMidazol-1-yl)-1-piperidinyl]-1-Methylethyl-2-naphthalenecarboxaMide CAY10593 VU 0155069
CAS:1130067-06-9
MF:C26H27CIN4O2.HCl
MW:462.97
EINECS:
Product Categories:
Mol File:1130067-06-9.mol
N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide Structure
N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide Chemical Properties
density 1.291±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility insoluble in EtOH; insoluble in H2O; ≥25.15 mg/mL in DMSO
pka11.11±0.30(Predicted)
form Pale-yellow solid.
Safety Information
HS Code 2933998090
MSDS Information
N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide Usage And Synthesis
UsesVU0155069 is a potent and specific inhibitor of phospholipase D1.
Biological Activityvu 0155069 is a selective phospholipase d1 (pld1) inhibitor, with an ic50 value of 46 nm [1].pld1 is one of the main pld isoforms in mammals. pld is an important enzyme responsible for the production of the lipid second messenger, i.e. phosphatidic acid which participates in both g protein-coupled receptor and receptor tyrosine kinase signal transduction networks [1].in calu-1 and hek293-gfppld2 cells, vu 0155069 blocked both pld1 and pld2 activity at the concentration of 20 μm, whilst preferentially inhibited pld1 at a lower concentration of 200 nm. in 4t1 cells, pld1-preferring vu 0155069 at 200 nm significantly decreased cell migration compared with the vehicle control [1].in mice bearing hepatocellular carcinoma xenografts, vu 0155069 (5 mg/kg, 50 μl, s.c., on alternate days) significantly reduced xenograft tumor size and weight. furthermore, vu 0155069 treatment substantially reduced both proliferating cell nuclear antigen- (pcna-) and ki67-positive cell populations in skin xenograft tumors [2].[1]. scott s a, selvy p e, buck j r, et al. design of isoform-selective phospholipase d inhibitors that modulate cancer cell invasiveness. nature chemical biology, 2009, 5(2): 108-117.[2]. xiao j, sun q, bei y, et al. therapeutic inhibition of phospholipase d1 suppresses hepatocellular carcinoma. clinical science, 2016, 130(13): 1125-1136.
N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide Preparation Products And Raw materials
Tag:N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide(1130067-06-9) Related Product Information
[2-(3,4-dimethylphenyl)-3-pyrrol-1-yl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-pyrazin-2-ylmethanone N[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-3-carboxamide Hydrochloride VU 591 hydrochloride VU0155041 2-Naphthalenecarboxamide, N-[(1S)-2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-, hydrochloride (1:1) N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecanedihydrochloride