- Melanotan 1
-
- $1.00 / 1g
-
2024-04-25
- CAS:75921-69-6
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 100kg
- Melanotan I
-
- $55.00 / 1Box
-
2024-04-24
- CAS:75921-69-6
- Min. Order: 1Box
- Purity: 99.99%
- Supply Ability: 10000000000
Related articles - Introduction of Melanotan I
- Melanotan I（Afamelanotide） is a first-in-class, synthetic, 13-amino acid peptide analogue of the endogenous alpha melanocyte-s....
- Nov 24，2021
|
| | Melanotan 1 Chemical Properties |
| density | 1.46±0.1 g/cm3(Predicted) | | RTECS | OS1830200 | | storage temp. | −20°C | | form | Solid | | pka | 4.43±0.10(Predicted) | | Water Solubility | Soluble to 0.60 mg/ml in sterile water | | Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 | | InChIKey | UAHFGYDRQSXQEB-LEBBXHLNSA-N | | CAS DataBase Reference | 75921-69-6(CAS DataBase Reference) |
| | Melanotan 1 Usage And Synthesis |
| Features | Afamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone. | | Uses | Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes. | | Definition | ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug. | | General Description | [Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation. | | Biochem/physiol Actions | [Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases. | | Side effects | The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.
| | storage | Store at -20°C |
| | Melanotan 1 Preparation Products And Raw materials |
|