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| | 1-Fluoro-cyclopropanecarboxylic acid Basic information |
| Product Name: | 1-Fluoro-cyclopropanecarboxylic acid | | Synonyms: | 1-Fluoro-cyclopropanecarboxylic acid;1-Fluorocyclopropanecarboxylic;1-Fluorocyclopropane-1-carboxylicacid;1-Fluoro-Cyclopropanecarboxylic Acid(WXFC0175);Cyclopropanecarboxylic acid, 1-fluoro-;Fluorocyclopropanecarboxylic acid | | CAS: | 137081-41-5 | | MF: | C4H5FO2 | | MW: | 104.08 | | EINECS: | 200-100-1 | | Product Categories: | cyclopropane | | Mol File: | 137081-41-5.mol |  |
| | 1-Fluoro-cyclopropanecarboxylic acid Chemical Properties |
| Melting point | 63-67℃ | | Boiling point | 120-125℃ (100 Torr) | | density | 1.36±0.1 g/cm3 (20 ºC 760 Torr) | | Fp | 56.6±22.6℃ | | storage temp. | Inert atmosphere,Room Temperature | | form | powder to crystal | | pka | 2.61±0.20(Predicted) | | color | White to Almost white | | InChI | InChI=1S/C4H5FO2/c5-4(1-2-4)3(6)7/h1-2H2,(H,6,7) | | InChIKey | NDCPERCVXDYEFU-UHFFFAOYSA-N | | SMILES | C1(F)(C(O)=O)CC1 |
| Safety Statements | 24/25 | | RIDADR | UN3261 | | HS Code | 29162090 |
| | 1-Fluoro-cyclopropanecarboxylic acid Usage And Synthesis |
| Chemical Properties | 1-Fluorocyclopropanecarboxylic acid is easy to react with metal ions, π-π and other non-covalent bonds, which is an important fragment for the construction of diversified organic structures; there is cyclopropane in its structure, which is easy to undergo nucleophilic substitution reactions. | | Uses | 1-Fluorocyclopropane-1-carboxylic acid | | Synthesis | General procedure for the synthesis of 1-fluorocyclopropanecarboxylic acid from 1-fluorocyclopropylmethyl ketone: Bromine (14.8 g, 93 mmol) was slowly added to a solution of sodium hydroxide (12.36 g, 300 mmol) in water (50 mL) at below 10 °C. Subsequently, 1-(1-fluorocyclopropyl)ethanone (3.3 g, 30 mmol) was added. The reaction mixture was slowly cooled to below 0°C and then stirred at room temperature for 1 hour. Sodium metabisulfite was added until the solution became colorless. Ethyl acetate (50 mL) was added, and the aqueous phase was separated and acidified with hydrochloric acid (2 M) to pH 2. The aqueous phase was extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give 1-fluorocyclopropanecarboxylic acid as a white solid (2.2 g, 66% yield).1H NMR (CDCl3, 400 MHz): δ 1.49-1.45 (m, 4H). | | References | [1] Journal of Molecular Structure, 2004, vol. 695-696, p. 163 - 169
[2] Patent: US2014/107340, 2014, A1. Location in patent: Paragraph 0112
[3] Patent: US5126338, 1992, A |
| | 1-Fluoro-cyclopropanecarboxylic acid Preparation Products And Raw materials |
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